ID   A0A183H4Y8_9BILA        Unreviewed;       353 AA.
AC   A0A183H4Y8;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   22-FEB-2023, entry version 19.
DE   SubName: Full=PAP2_C domain-containing protein {ECO:0000313|WBParaSite:OFLC_0000254701-mRNA-1};
GN   ORFNames=OFLC_LOCUS2548 {ECO:0000313|EMBL:VDO33365.1}, X798_02675
GN   {ECO:0000313|EMBL:OZC10368.1};
OS   Onchocerca flexuosa.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=387005 {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0000254701-mRNA-1};
RN   [1] {ECO:0000313|EMBL:OZC10368.1, ECO:0000313|Proteomes:UP000242913}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Red Deer {ECO:0000313|EMBL:OZC10368.1};
RA   Mitreva M.;
RT   "Draft genome of the nematode, Onchocerca flexuosa.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:OFLC_0000254701-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:VDO33365.1, ECO:0000313|Proteomes:UP000267606}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the sphingomyelin synthase family.
CC       {ECO:0000256|ARBA:ARBA00005441}.
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DR   EMBL; KZ269987; OZC10368.1; -; Genomic_DNA.
DR   EMBL; UZAJ01001486; VDO33365.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A183H4Y8; -.
DR   STRING; 387005.A0A183H4Y8; -.
DR   WBParaSite; OFLC_0000254701-mRNA-1; OFLC_0000254701-mRNA-1; OFLC_0000254701.
DR   Proteomes; UP000050787; Unplaced.
DR   Proteomes; UP000242913; Unassembled WGS sequence.
DR   Proteomes; UP000267606; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016780; F:phosphotransferase activity, for other substituted phosphate groups; IEA:InterPro.
DR   GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR045221; Sphingomyelin_synth-like.
DR   InterPro; IPR025749; Sphingomyelin_synth-like_dom.
DR   PANTHER; PTHR21290:SF27; PHOSPHATIDYLCHOLINE:CERAMIDE CHOLINEPHOSPHOTRANSFERASE 1; 1.
DR   PANTHER; PTHR21290; SPHINGOMYELIN SYNTHETASE; 1.
DR   Pfam; PF14360; PAP2_C; 1.
PE   3: Inferred from homology;
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000242913};
KW   Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        78..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        119..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        155..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        223..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        278..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          220..292
FT                   /note="Sphingomyelin synthase-like"
FT                   /evidence="ECO:0000259|Pfam:PF14360"
SQ   SEQUENCE   353 AA;  39916 MW;  2B670C49D7839CCB CRC64;
     MLDGQISIAS SAVRRICSSS NSEDFSEDNY GNEGRAPLLN GVLSSADNAV KIDLNLSDII
     IQTSNSSADK FPRERCKAAI SVGLLITAAI CNDLVLSFIH EKVPQEPPLP DAIFAHTPYI
     PWALILSEYL MLASLTCMVA LTIIHRHRWI ILRRIAVIAS LLYFGRCLTM LVTQVPIADP
     NYYCSPRLSG ADYTLRNIVL RAMRIGSGAG LIINGKHTLC GDYIYSGHTV VLVITCLFIT
     EYSPRRWKPL HFFSIMVSTA GVILLLISRA HYTIDVIISY WVTTRIFWTY HTLAAIPSLR
     NASSHYNHLS KLYWYRLFLF MEGNLHRPVP RRFDWPFPRM RFGTRTICKT NLS
//