ID   A0A183H6U5_9BILA        Unreviewed;       556 AA.
AC   A0A183H6U5;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   08-NOV-2023, entry version 22.
DE   SubName: Full=Rap-GAP domain-containing protein {ECO:0000313|WBParaSite:OFLC_0000320601-mRNA-1};
GN   ORFNames=OFLC_LOCUS3206 {ECO:0000313|EMBL:VDO35665.1};
OS   Onchocerca flexuosa.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=387005 {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0000320601-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:OFLC_0000320601-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDO35665.1, ECO:0000313|Proteomes:UP000267606}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UZAJ01002072; VDO35665.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A183H6U5; -.
DR   STRING; 387005.A0A183H6U5; -.
DR   WBParaSite; OFLC_0000320601-mRNA-1; OFLC_0000320601-mRNA-1; OFLC_0000320601.
DR   Proteomes; UP000050787; Unplaced.
DR   Proteomes; UP000267606; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   InterPro; IPR027107; Tuberin/Ral-act_asu.
DR   PANTHER; PTHR10063:SF11; RHO GTPASE-ACTIVATING PROTEIN CG5521-RELATED; 1.
DR   PANTHER; PTHR10063; TUBERIN; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468}.
FT   DOMAIN          464..556
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
SQ   SEQUENCE   556 AA;  62822 MW;  DB5D8BB4D1E33B98 CRC64;
     MKHYTALGIN NNSFNFQTVS KTINTLLRLS GTDALIHWIC TRLLLLPPSG QAHCLPAYCA
     VLSTINPPPL IEAHILLALT RAIVSERFTI VLEYMPFMSK DYLTILARPA LSSLTQLIKQ
     SNFSPRSVQV AALLSPDHAV GETLLLNLLA LNSDEVPLQS YSLALHALAL LIIERADTKL
     MTEVMNRVCT LKTSASLLHM FCADLNQLKQ LNLRDKLVTI LEQALDFVKE NCLAGEILWQ
     SISTNLMDCQ LRRSLLERVL NDKRLCLEGF LLTYYRQFPL PSFALGHYDS VENITGNSQQ
     DALIAGRVFF DQGRAILSVD MDSGLRLTSR TPVGKHCWCF TREHAIRRQM NCVNNWLWKL
     ALRPKKITVE ITSNKVTTED PFDKLPQLPR TLQADPIECN EMYFLIQQNR RLITSAPTFC
     RPEPMECSSR SLTEEKYVLW RTFAADLRLF SGMRQIPPSF NRDIRHLDHT CSREVHKVAV
     IYVAKGQEDK VSILSNSFGS AAFNEFVLRL GWQVQVGHQH YGYSGGLPNG VTAPYYASAD
     TEIIFHVSTM LDGSFL
//