ID   A0A183H7J3_9BILA        Unreviewed;       331 AA.
AC   A0A183H7J3;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   08-NOV-2023, entry version 23.
DE   RecName: Full=Protein-tyrosine sulfotransferase {ECO:0000256|ARBA:ARBA00013262, ECO:0000256|RuleBase:RU365018};
DE            EC=2.8.2.20 {ECO:0000256|ARBA:ARBA00013262, ECO:0000256|RuleBase:RU365018};
GN   ORFNames=OFLC_LOCUS3455 {ECO:0000313|EMBL:VDO36552.1};
OS   Onchocerca flexuosa.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=387005 {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0000345401-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:OFLC_0000345401-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDO36552.1, ECO:0000313|Proteomes:UP000267606}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the O-sulfation of tyrosine residues within acidic
CC       motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as
CC       cosubstrate. {ECO:0000256|RuleBase:RU365018}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3'-phosphoadenylyl sulfate + L-tyrosyl-[protein] = adenosine
CC         3',5'-bisphosphate + H(+) + O-sulfo-L-tyrosine-[protein];
CC         Xref=Rhea:RHEA:16801, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:11688,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:46858, ChEBI:CHEBI:58339,
CC         ChEBI:CHEBI:58343, ChEBI:CHEBI:65286; EC=2.8.2.20;
CC         Evidence={ECO:0000256|ARBA:ARBA00000411,
CC         ECO:0000256|RuleBase:RU365018};
CC   -!- SIMILARITY: Belongs to the protein sulfotransferase family.
CC       {ECO:0000256|ARBA:ARBA00009988, ECO:0000256|RuleBase:RU365018}.
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DR   EMBL; UZAJ01002310; VDO36552.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A183H7J3; -.
DR   STRING; 387005.A0A183H7J3; -.
DR   WBParaSite; OFLC_0000345401-mRNA-1; OFLC_0000345401-mRNA-1; OFLC_0000345401.
DR   Proteomes; UP000050787; Unplaced.
DR   Proteomes; UP000267606; Unassembled WGS sequence.
DR   GO; GO:0008476; F:protein-tyrosine sulfotransferase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR026634; TPST-like.
DR   PANTHER; PTHR12788:SF10; PROTEIN-TYROSINE SULFOTRANSFERASE; 1.
DR   PANTHER; PTHR12788; PROTEIN-TYROSINE SULFOTRANSFERASE 2; 1.
DR   Pfam; PF13469; Sulfotransfer_3; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365018}.
SQ   SEQUENCE   331 AA;  37782 MW;  9B61FA427B54CD3D CRC64;
     MVSVSGLSWR PNLRYNLSMM LMRGRVRMIL LITMLMGCLL YMLISASSLY PTFNVLRNNT
     VILPGQKMNT LSKYSSLIFI GGVPRSGTTL IRAMLDAHPS VRCGEETRVI PRILGLRTQW
     RKNQKEWNRL KEAGVTDEVI NDAITSFILQ VIAGHGKPAE RLCNKDPFTM KSAEYLAYLF
     PNSKFLLMIR DGRATVHSII SRQVTITGFD LNDPKQCLDK WNHIIKIMYE QCRAIGKKRC
     LMVYYEQLVL HPEQQLRRVL DFLNIAWSDL VLHHDKLIGK DISLVERSTD QVIKPVNLDA
     LTKWVGTFGE DVIQEMASLA PMLAELGFVI L
//