ID   A0A183H7W0_9BILA        Unreviewed;       308 AA.
AC   A0A183H7W0;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Inositol 1,4,5-trisphosphate receptor {ECO:0000256|RuleBase:RU368044};
GN   ORFNames=OFLC_LOCUS3571 {ECO:0000313|EMBL:VDO36999.1};
OS   Onchocerca flexuosa.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=387005 {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0000357101-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:OFLC_0000357101-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDO36999.1, ECO:0000313|Proteomes:UP000267606}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger
CC       that mediates the release of intracellular calcium.
CC       {ECO:0000256|RuleBase:RU368044}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|RuleBase:RU368044}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU368044}.
CC   -!- DOMAIN: The receptor contains a calcium channel in its C-terminal
CC       extremity. Its large N-terminal cytoplasmic region has the ligand-
CC       binding site in the N-terminus and modulatory sites in the middle
CC       portion immediately upstream of the channel region.
CC       {ECO:0000256|RuleBase:RU368044}.
CC   -!- SIMILARITY: Belongs to the InsP3 receptor family.
CC       {ECO:0000256|RuleBase:RU368044}.
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DR   EMBL; UZAJ01002432; VDO36999.1; -; Genomic_DNA.
DR   STRING; 387005.A0A183H7W0; -.
DR   WBParaSite; OFLC_0000357101-mRNA-1; OFLC_0000357101-mRNA-1; OFLC_0000357101.
DR   Proteomes; UP000050787; Unplaced.
DR   Proteomes; UP000267606; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.80.10.50; -; 1.
DR   Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_IP3_receptor.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715:SF99; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; 1.
DR   PANTHER; PTHR13715; RYANODINE RECEPTOR AND IP3 RECEPTOR; 1.
DR   Pfam; PF01365; RYDR_ITPR; 1.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 1.
DR   SUPFAM; SSF82109; MIR domain; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU368044};
KW   Calcium channel {ECO:0000256|RuleBase:RU368044};
KW   Calcium transport {ECO:0000256|RuleBase:RU368044};
KW   Endoplasmic reticulum {ECO:0000256|RuleBase:RU368044};
KW   Ion channel {ECO:0000256|RuleBase:RU368044};
KW   Ion transport {ECO:0000256|RuleBase:RU368044};
KW   Ligand-gated ion channel {ECO:0000256|RuleBase:RU368044};
KW   Membrane {ECO:0000256|RuleBase:RU368044};
KW   Receptor {ECO:0000256|RuleBase:RU368044};
KW   Transport {ECO:0000256|RuleBase:RU368044}.
FT   DOMAIN          104..301
FT                   /note="RIH"
FT                   /evidence="ECO:0000259|Pfam:PF01365"
SQ   SEQUENCE   308 AA;  35941 MW;  8F4AD80F417B3AD8 CRC64;
     MDVRISQRTY VRLLHVCTNT WIHTTDPIEK RNLYHFSKNE KGWVKVVSEN FKIDKETFAL
     LPVRPDEVRD LDFANDACKA LHGFVKLIES GQIVSKEPMN ITIQLLTECI YFVTNQSNHL
     TDPIKIVDFK PPRDRQKLLR EQGVLDQIFA LLRVPFLPRN GNDPEPLLSS PRKLSEQGNE
     IFKRIFHLCY SLLRYSQVGY RKNQEYLAEK FGQIQEQIGF DLLAEDTMTA VLHNNPKLLE
     KYVKNPHVER FVELVRENKA GRFLDYLADL CVCRGEANKK IQELICSCVL SETNRDIFIN
     TIINDKKF
//