ID   A0A183H944_9BILA        Unreviewed;       359 AA.
AC   A0A183H944;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Reduced folate carrier {ECO:0000313|WBParaSite:OFLC_0000400501-mRNA-1};
GN   ORFNames=OFLC_LOCUS4013 {ECO:0000313|EMBL:VDO38584.1};
OS   Onchocerca flexuosa.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=387005 {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0000400501-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:OFLC_0000400501-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDO38584.1, ECO:0000313|Proteomes:UP000267606}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the reduced folate carrier (RFC) transporter (TC
CC       2.A.48) family. {ECO:0000256|ARBA:ARBA00005773}.
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DR   EMBL; UZAJ01002891; VDO38584.1; -; Genomic_DNA.
DR   WBParaSite; OFLC_0000400501-mRNA-1; OFLC_0000400501-mRNA-1; OFLC_0000400501.
DR   Proteomes; UP000050787; Unplaced.
DR   Proteomes; UP000267606; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0090482; F:vitamin transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR   InterPro; IPR002666; Folate_carrier.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   NCBIfam; TIGR00806; rfc; 1.
DR   PANTHER; PTHR10686; FOLATE TRANSPORTER; 1.
DR   PANTHER; PTHR10686:SF20; FOLATE TRANSPORTER 1; 1.
DR   Pfam; PF01770; Folate_carrier; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        52..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        78..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        108..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        163..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        243..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        280..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        310..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        333..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   359 AA;  41345 MW;  8635B5AD65968CA7 CRC64;
     MYWKHIAYLM CLFGLIKKFR PATPFITPFL ISSYKNFTDV QLYSQIYPLW TYSYLIAMVN
     LYFQIPIFFL TDILRHKPIV VLEALSYCIS HIIILWGNEV WQMQLMEIIF GISTASDIAY
     VSYMYAIVDQ KYFKRITSYV RAATLFGKFL AYGSGQLLIS THLISFGSGC ITLLMACLLP
     TISSKIVQNK NLQEVENCDQ IIEISGDERV SLNAISPTVV PGMKSYFRDA WTHMMIFKSK
     TNVFKWYIWW AFAGCGTFQV QNYVQNLWAL LQQNDKAYNG ITECTATLIG AIACFFVQYL
     KVDWAKCGEL VLWVNSIISA ILLIIMSQTT SAFMAYILYI AFAIIYQLLM TAARFTIKY
//