ID A0A183HDI6_9BILA Unreviewed; 181 AA.
AC A0A183HDI6;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=LITAF domain-containing protein {ECO:0000313|WBParaSite:OFLC_0000554701-mRNA-1};
GN ORFNames=OFLC_LOCUS5549 {ECO:0000313|EMBL:VDO43508.1}, X798_03705
GN {ECO:0000313|EMBL:OZC09363.1};
OS Onchocerca flexuosa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=387005 {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0000554701-mRNA-1};
RN [1] {ECO:0000313|EMBL:OZC09363.1, ECO:0000313|Proteomes:UP000242913}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Red Deer {ECO:0000313|EMBL:OZC09363.1};
RA Mitreva M.;
RT "Draft genome of the nematode, Onchocerca flexuosa.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:OFLC_0000554701-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [3] {ECO:0000313|EMBL:VDO43508.1, ECO:0000313|Proteomes:UP000267606}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004125}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004125}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004125}. Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004630}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004630}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004630}.
CC -!- SIMILARITY: Belongs to the CDIP1/LITAF family.
CC {ECO:0000256|ARBA:ARBA00005975}.
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DR EMBL; KZ269995; OZC09363.1; -; Genomic_DNA.
DR EMBL; UZAJ01004828; VDO43508.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A183HDI6; -.
DR STRING; 387005.A0A183HDI6; -.
DR WBParaSite; OFLC_0000554701-mRNA-1; OFLC_0000554701-mRNA-1; OFLC_0000554701.
DR Proteomes; UP000050787; Unplaced.
DR Proteomes; UP000242913; Unassembled WGS sequence.
DR Proteomes; UP000267606; Unassembled WGS sequence.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR006629; LITAF.
DR InterPro; IPR037519; LITAF_fam.
DR PANTHER; PTHR23292; LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR; 1.
DR PANTHER; PTHR23292:SF5; LITAF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF10601; zf-LITAF-like; 1.
DR SMART; SM00714; LITAF; 1.
DR PROSITE; PS51837; LITAF; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000242913};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT TRANSMEM 127..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 88..171
FT /note="LITAF"
FT /evidence="ECO:0000259|PROSITE:PS51837"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..26
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 181 AA; 20563 MW; 88584F219AF83D0E CRC64;
MGEVEEPIRK STPPPPYSPE RPPPPYSKML DVDLNEIKKK EEIDCNTPHL PCTPFSSGSV
HPRLSSTPAT IISNSEGINP SSGPSNTSFT VANYTVKRAT TAEPHDEFCP KCQCQIRTKQ
RHKSGRLTWI LVFIILIIFF PLAFVPFLID SCKDVRHYCP KCNMLLSVKK RIFFSLRFLR
K
//
