ID A0A183HW91_9BILA Unreviewed; 215 AA.
AC A0A183HW91;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 31 {ECO:0000256|RuleBase:RU364129};
GN ORFNames=OFLC_LOCUS11753 {ECO:0000313|EMBL:VDO78945.1};
OS Onchocerca flexuosa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=387005 {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0001175301-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:OFLC_0001175301-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDO78945.1, ECO:0000313|Proteomes:UP000267606}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364129}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364129}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364129}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 31 family.
CC {ECO:0000256|ARBA:ARBA00006378, ECO:0000256|RuleBase:RU364129}.
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DR EMBL; UZAJ01017413; VDO78945.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A183HW91; -.
DR STRING; 387005.A0A183HW91; -.
DR WBParaSite; OFLC_0001175301-mRNA-1; OFLC_0001175301-mRNA-1; OFLC_0001175301.
DR Proteomes; UP000050787; Unplaced.
DR Proteomes; UP000267606; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.10.10.1340; Mediator of RNA polymerase II, submodule Med31 (Soh1); 1.
DR InterPro; IPR021852; DUF3456.
DR InterPro; IPR038089; Med31_sf.
DR InterPro; IPR008831; Mediator_Med31.
DR PANTHER; PTHR13186; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31; 1.
DR PANTHER; PTHR13186:SF0; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31; 1.
DR Pfam; PF11938; DUF3456; 1.
DR Pfam; PF05669; Med31; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU364129};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364129};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364129};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364129}.
FT DOMAIN 157..209
FT /note="DUF3456"
FT /evidence="ECO:0000259|Pfam:PF11938"
SQ SEQUENCE 215 AA; 25461 MW; 6F30710ABC4D7960 CRC64;
FFFFLVFCRA LKYPQCLHFL EAVQSSAFRE AVTCTANAKF IEEQQLLQWQ YYTRKRQRLH
VSFIYYFEIP FPKEREKLCI QQNTMMMSRN GSNNNHHNGK KVQRHPPNFF SSLLVILIIY
LKSFVITAEP TIDLPSRCES CVLFAREFEE QLADDRNFKI SAVERELKFV EALEGTCKRM
LQYKLHKEKS DISRFAKEES STMKALNELR SKGVK
//
