ID A0A183HY70_9BILA Unreviewed; 658 AA.
AC A0A183HY70;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=receptor protein serine/threonine kinase {ECO:0000256|ARBA:ARBA00012401};
DE EC=2.7.11.30 {ECO:0000256|ARBA:ARBA00012401};
GN ORFNames=OFLC_LOCUS12432 {ECO:0000313|EMBL:VDP11304.1};
OS Onchocerca flexuosa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=387005 {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0001243301-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:OFLC_0001243301-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDP11304.1, ECO:0000313|Proteomes:UP000267606}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC protein kinase family. TGFB receptor subfamily.
CC {ECO:0000256|ARBA:ARBA00009605}.
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DR EMBL; UZAJ01039842; VDP11304.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A183HY70; -.
DR STRING; 387005.A0A183HY70; -.
DR WBParaSite; OFLC_0001243301-mRNA-1; OFLC_0001243301-mRNA-1; OFLC_0001243301.
DR Proteomes; UP000050787; Unplaced.
DR Proteomes; UP000267606; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR Gene3D; 2.10.60.10; CD59; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR003605; GS_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR InterPro; IPR000333; TGFB_receptor.
DR PANTHER; PTHR23255:SF68; RECEPTOR PROTEIN SERINE/THREONINE KINASE; 1.
DR PANTHER; PTHR23255; TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00467; GS; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF57302; Snake toxin-like; 1.
DR PROSITE; PS51256; GS; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 18..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 267..297
FT /note="GS"
FT /evidence="ECO:0000259|PROSITE:PS51256"
FT DOMAIN 298..638
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 50..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 636..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..658
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 326
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 658 AA; 73582 MW; 6580DDA85C80353F CRC64;
MFTNYSVVAL PRMELVKLWI SEVVETFTAL LLLGILLSVN GNLQEYGRKQ DHDSAERYDA
DGDLSMPTDV QGRPYQFNSS RVESEADRKR KSAPAKYEDE RSFCYCNYAP EFCGGFTNFT
CIKHLEASCF HFTEEIYDKT LKQVETVHLF GCAPLTHGSG GSYFTCKAHL VAHARPKSIA
CCQEGNYCNR NLSVPAYINV SPEGIIVDHY TFSYMTITVI IYVVIFSLFS GIALLLFWRR
NFIVIYFTAE KLKPSLQKST VQLMDAGEIE KAPMLYDVSS GSGSGFASLN QRTVAQDLQF
LSIVGKGRYG EVKKACYRGD RIVAVKTFYT TEEDSWKNEK EIYQTQMLNH ENILQFVAAD
IGSEDSITRM LLITDFHAYG SLFEYLQRGE TLSVSEALHL AYSAVCGLEH LHSALHGTGT
PQKPAIAHRD VKSKNIIVKR PYVCCIADFG LALTEDMVKI KTDINIQVGT KRYMAPEVLD
KSLNVKNFHH FKMADIYSFA LVIWEILRRI QEDNRLSRAS ESDSGIGSSG SGSGTTKLMS
GFIANLDASG YITNVSSNVV DHQSISENSM PLKARPPMQP FDGMVDPDPS FEQMRRLPCL
KEICELISEC WNASIDCRHT ALRVKRKIKD TVLKHKGLGG SQTSGSTKQD CSAKSLSV
//