ID A0A183I1J4_9BILA Unreviewed; 404 AA.
AC A0A183I1J4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Neural Wiskott-Aldrich syndrome protein-like {ECO:0000313|WBParaSite:OFLC_0001360701-mRNA-1};
GN ORFNames=OFLC_LOCUS13606 {ECO:0000313|EMBL:VDP14194.1};
OS Onchocerca flexuosa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=387005 {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0001360701-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:OFLC_0001360701-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDP14194.1, ECO:0000313|Proteomes:UP000267606}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UZAJ01040290; VDP14194.1; -; Genomic_DNA.
DR STRING; 387005.A0A183I1J4; -.
DR WBParaSite; OFLC_0001360701-mRNA-1; OFLC_0001360701-mRNA-1; OFLC_0001360701.
DR Proteomes; UP000050787; Unplaced.
DR Proteomes; UP000267606; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR CDD; cd00132; CRIB; 1.
DR CDD; cd01205; EVH1_WASP-like; 1.
DR Gene3D; 3.90.810.10; CRIB domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR011026; WAS_C.
DR InterPro; IPR033927; WASPfam_EVH1.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR PANTHER; PTHR11202:SF36; NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN; 1.
DR PANTHER; PTHR11202; SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF00786; PBD; 1.
DR Pfam; PF00568; WH1; 1.
DR SMART; SM00285; PBD; 1.
DR SMART; SM00461; WH1; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47912; Wiscott-Aldrich syndrome protein, WASP, C-terminal domain; 1.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS50229; WH1; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 51..163
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT DOMAIN 247..260
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT REGION 227..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..341
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..388
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 404 AA; 43985 MW; AAAB140B1D17269A CRC64;
MHSGGTATGA YQFSVQHVGL NNTPTGRPKK RPPNTGALLF NSVENSMLFS LLGHDCISLA
AGVVQLLKSD PQNPGVWIKT HRGVVSLVKD YDKRAYFLRL YDIYRKQYLW QQMLYKNFHA
SQPLGCPHLL TFEGDECVFG LNFSSKEEAY SFKCHLDKRY EQEKKSQEKE MLATSGSQNF
LSSSGGSQLL PGGRTHAVSV PHRTGITSIG TVPNIGGGAW TNFVTINRTK KKNSKKEKKQ
KIRKEDISNP TNFQHKAHLG WNQDGGFSQE TYNYDPMDDS VKAVLRAAGE NPERMSKDDL
EFSKNFFQPP SAMNEAPTTY RPNDVPPPPP PPPPPSNSTC SVPTAPTPSS LSTISSLAPP
PPPPPPPPLT YASSTVPPPP PPPPLSYASP LSSGGGGGKT SLLS
//
