ID   A0A183I251_9BILA        Unreviewed;       825 AA.
AC   A0A183I251;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=TyrKc domain-containing protein {ECO:0000313|WBParaSite:OFLC_0001381401-mRNA-1};
GN   ORFNames=OFLC_LOCUS13813 {ECO:0000313|EMBL:VDP14727.1};
OS   Onchocerca flexuosa.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=387005 {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0001381401-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:OFLC_0001381401-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDP14727.1, ECO:0000313|Proteomes:UP000267606}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UZAJ01040410; VDP14727.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A183I251; -.
DR   STRING; 387005.A0A183I251; -.
DR   WBParaSite; OFLC_0001381401-mRNA-1; OFLC_0001381401-mRNA-1; OFLC_0001381401.
DR   Proteomes; UP000050787; Unplaced.
DR   Proteomes; UP000267606; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   PANTHER; PTHR24416:SF617; RECEPTOR PROTEIN-TYROSINE KINASE; 1.
DR   PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           30..825
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5033261461"
FT   TRANSMEM        584..605
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          541..787
FT                   /note="Tyrosine-protein kinase catalytic"
FT                   /evidence="ECO:0000259|SMART:SM00219"
SQ   SEQUENCE   825 AA;  94767 MW;  A68B798E9DD1A199 CRC64;
     MHIPWVLHLI TIILTCCSVF HSTLDVTYAD YKDPFTDNGL FSTSNNKSSK AIRIKYPSFT
     EVHGITIYEK LLATALDNII IVYDISSSVR IENVHRIQLP KSIRGKLLEF KFIDHEMLLF
     CDALTCRLCM LTSPEKPCVE YLLTLNGKKT EELLCATAVK DSSQNINIRI VTKHANHAAI
     LRFPSYYTIS KTDKLVSLQS AEDIRIIDEH SLATAFNRRG YTFFVGSARR PYEPYINARI
     EELIVMSVRI TRICDKDRTE KLESRIDMAL TCGNFSKFIQ LLFKSNVLGL RTNVVSLAAE
     YDRDSDELIV VFQTTEKNEN VACKYNMDLE CQKVQNLNEL PPHCFIFSRR ADGHAMRTCS
     KFGGVSHQTH QMTSSILWSL QLQQPQLPEQ SRTFQFRIAA DLSRRRIYFV QDNDLSYTEL
     SCSYFYDSCD SLEQSNWSDP LQCLWCAMNN GSGYAFPRSK GIDCPFYTVD NLCAPFIEHV
     NIPSSNFLNY TSFEVYGRKF DRLQDIVVKV CNQNCTISHL GSAKLSCTVN RPSNAMENCN
     FYLEGKLGSL GRFNITFEVP KKRDSHITSI ILASTHSHSK YSRAVATIFA VIVLSFLIVL
     ILCLLRQFHK RKQKRMKQCG KSGSQISLDT SHAPFVNNNP FSSLKRKGDE IKTFNPYENL
     FLEIDPKLQI SLKNLELGDE IGKGNADLPN ILLLDAYLVV KIADFGLSRD VSQCGMYQAI
     HKDRGIPIRW MPIESLEEQQ VSLFIHFRQF ISFLFSENFF LYYHVMRRCW MEDPKRRPTF
     FELTEMMEDV VRQLRRGVTS GAFLDSHYER VSARSFTTSL NNISN
//