ID   A0A183I2S9_9BILA        Unreviewed;       397 AA.
AC   A0A183I2S9;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Nuclear transcription factor Y subunit beta {ECO:0000256|ARBA:ARBA00015277};
DE   AltName: Full=CAAT box DNA-binding protein subunit B {ECO:0000256|ARBA:ARBA00029965};
DE   AltName: Full=Nuclear transcription factor Y subunit B {ECO:0000256|ARBA:ARBA00031126};
GN   ORFNames=OFLC_LOCUS14041 {ECO:0000313|EMBL:VDP15346.1};
OS   Onchocerca flexuosa.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=387005 {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0001404901-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:OFLC_0001404901-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDP15346.1, ECO:0000313|Proteomes:UP000267606}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the sequence-specific heterotrimeric
CC       transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3'
CC       box motif found in the promoters of its target genes. NF-Y can function
CC       as both an activator and a repressor, depending on its interacting
CC       cofactors. {ECO:0000256|ARBA:ARBA00025263}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the NFYB/HAP3 subunit family.
CC       {ECO:0000256|ARBA:ARBA00009053}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; UZAJ01040555; VDP15346.1; -; Genomic_DNA.
DR   STRING; 387005.A0A183I2S9; -.
DR   WBParaSite; OFLC_0001404901-mRNA-1; OFLC_0001404901-mRNA-1; OFLC_0001404901.
DR   Proteomes; UP000050787; Unplaced.
DR   Proteomes; UP000267606; Unassembled WGS sequence.
DR   GO; GO:0016602; C:CCAAT-binding factor complex; IEA:InterPro.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR   InterPro; IPR003958; CBFA_NFYB_domain.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR027113; Transc_fact_NFYB/HAP3.
DR   InterPro; IPR003956; Transcrpt_fac_NFYB/HAP3_CS.
DR   PANTHER; PTHR11064; CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED; 1.
DR   PANTHER; PTHR11064:SF9; NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA; 1.
DR   Pfam; PF00808; CBFD_NFYB_HMF; 1.
DR   PRINTS; PR00615; CCAATSUBUNTA.
DR   SUPFAM; SSF47113; Histone-fold; 1.
DR   PROSITE; PS00685; NFYB_HAP3; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          60..125
FT                   /note="Transcription factor CBF/NF-Y/archaeal histone"
FT                   /evidence="ECO:0000259|Pfam:PF00808"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          361..397
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..30
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        361..378
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        379..397
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   397 AA;  43550 MW;  46E2D9774987DE9A CRC64;
     MINEDDGNNY LDKYSQESDT CQAEGSTTED NNAERILTVA NIASEENSMA RKPILEQDRF
     LPIANISRLM KNMIPRSGKV AKDAKECVQE CVSEFISFIT SEACDRCLNA SEKRKTITGE
     DIIGAFSTLG FDNYVGPLSA YVRKFREAFR TERSNETLLV EPSGSHPSFL EKINVRDSNE
     SASSSDVFAI QTEPMASSST CTPQIIFAGE DDPDGAIRVM STGNVQHLQL LMDPATGQHY
     INVQNPNGTQ QLLPVQVTTV ADSSATPLTL PCADVQNLTD GKAIDKEMFN FSKIEFRNSL
     PKSDNIASTS YKELSCSIKC SFLNLGFPLN IFSNGSTYGL KHSSVGLSTA NQHKQQVPYA
     GNMGQFGHHS NSGDTSGGIR EQPRKRSHDS IDYISFD
//