ID   A0A183I2U9_9BILA        Unreviewed;       562 AA.
AC   A0A183I2U9;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=CULLIN_2 domain-containing protein {ECO:0000313|WBParaSite:OFLC_0001406901-mRNA-1};
GN   ORFNames=OFLC_LOCUS14061 {ECO:0000313|EMBL:VDP15393.1};
OS   Onchocerca flexuosa.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=387005 {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0001406901-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:OFLC_0001406901-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDP15393.1, ECO:0000313|Proteomes:UP000267606}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
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DR   EMBL; UZAJ01040570; VDP15393.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A183I2U9; -.
DR   STRING; 387005.A0A183I2U9; -.
DR   WBParaSite; OFLC_0001406901-mRNA-1; OFLC_0001406901-mRNA-1; OFLC_0001406901.
DR   Proteomes; UP000050787; Unplaced.
DR   Proteomes; UP000267606; Unassembled WGS sequence.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF76; CULLIN-5; 1.
DR   Pfam; PF00888; Cullin; 2.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
FT   DOMAIN          342..448
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   562 AA;  65657 MW;  F4E4A455BE761A9E CRC64;
     MVRKELEAEV HRYILTAERR IMQHEEENAI LRVYISEWTK FYTQTEYLPK PFSYISEQKN
     LSLKSKNPMK EAGVMVSSIM LNDWGKTIFV AIKHKLQNAA MRLVELERNG EAFDPQLVIG
     VRQSYVSLNL STEDSLAVYK ENFERAYVDD TERFYKSRAP QVLASEGVQS YMVYADTKLG
     EEEARGRRYL ESTTDSVEKL VERCVKVLVV QFQEQILAEC PTLINEGQIE KLRMLYRLIN
     RTSDGIDNVL KFLDIFIRTE ALNDMRANAN TITTDPEKYV EQLLTMFSKF SLLVADAFYD
     DPRFLTTRDK AFQDVVNDTC IFRMEITSSR GKCVGRMQAE SRCPELLANF TDLLLRKTSL
     SKRLSSEEID AKLNDVLLVL KYVQNKDVFM RFYKAHLTRR LILESILNAG AWSRGAADRT
     QVQMPRELED FIPEVEDFYR KQHSGRKLQW HHHWSHGTNG KEQNRGRINL IGRLQLSVET
     NVQEEHDDII ALRILRVQEA IVKIMKIRKQ CQSAQLQTEL IELLKHMFLP PKKMIKEQVE
     WLIENGFIAR DSNDLNMFLY IT
//