ID   A0A183I3B9_9BILA        Unreviewed;       342 AA.
AC   A0A183I3B9;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   13-SEP-2023, entry version 21.
DE   SubName: Full=CTLH domain-containing protein {ECO:0000313|WBParaSite:OFLC_0001423901-mRNA-1};
GN   ORFNames=OFLC_LOCUS14231 {ECO:0000313|EMBL:VDP16093.1};
OS   Onchocerca flexuosa.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=387005 {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0001423901-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:OFLC_0001423901-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDP16093.1, ECO:0000313|Proteomes:UP000267606}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UZAJ01040692; VDP16093.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A183I3B9; -.
DR   STRING; 387005.A0A183I3B9; -.
DR   WBParaSite; OFLC_0001423901-mRNA-1; OFLC_0001423901-mRNA-1; OFLC_0001423901.
DR   Proteomes; UP000050787; Unplaced.
DR   Proteomes; UP000267606; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   CDD; cd16652; dRING_Rmd5p-like; 1.
DR   InterPro; IPR024964; CTLH/CRA.
DR   InterPro; IPR006595; CTLH_C.
DR   InterPro; IPR045098; Fyv10_fam.
DR   InterPro; IPR037683; Rmd5_dRing.
DR   InterPro; IPR044063; ZF_RING_GID.
DR   PANTHER; PTHR12170:SF3; GH10162P; 1.
DR   PANTHER; PTHR12170; MACROPHAGE ERYTHROBLAST ATTACHER-RELATED; 1.
DR   Pfam; PF10607; CTLH; 1.
DR   SMART; SM00668; CTLH; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50897; CTLH; 1.
DR   PROSITE; PS51867; ZF_RING_GID; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU01215}.
FT   DOMAIN          92..145
FT                   /note="CTLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50897"
FT   DOMAIN          254..312
FT                   /note="RING-Gid-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51867"
FT   ZN_FING         254..312
FT                   /note="RING-Gid-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01215"
SQ   SEQUENCE   342 AA;  39128 MW;  633D094ECBC9EE4A CRC64;
     MEKLGDMLQE MAHQHRSTHQ MLSKIGRAID RYFVTDLSSL TKIDKNIDTD PRLHGRVNAL
     ITNHLTSTGK FDVADILTKE AQLPASEGLE FNVDDIRHLM EAFQKRDITP ALQWLKQNAS
     RDEQLIYDLQ KQHFVKLLED GQTMEALQYS RQLSKNPEEM MHLLWAVVAK DRKTRYPDLF
     NPVVWQQLEL RLARVMSRSE NYLSQILELG IKMVPSLISL RQLMVNRSLE SLFQGDELPI
     EVDVPNATHS VFACPILKAQ CTEQNPPMRL TCGHLISREA LHKLAQTGRF VAPTNLAPSN
     AFSHIRLKCP YCPVESSVAD AKRLETDLCR FSAFITQLIV SR
//