ID A0A183JHV6_9TREM Unreviewed; 335 AA.
AC A0A183JHV6;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=BHLH domain-containing protein {ECO:0000313|WBParaSite:SCUD_0000227901-mRNA-1};
GN ORFNames=SCUD_LOCUS2280 {ECO:0000313|EMBL:VDO73417.1};
OS Schistosoma curassoni.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6186 {ECO:0000313|Proteomes:UP000050789, ECO:0000313|WBParaSite:SCUD_0000227901-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:SCUD_0000227901-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDO73417.1, ECO:0000313|Proteomes:UP000279833}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dakar {ECO:0000313|EMBL:VDO73417.1}, and Dakar, Senegal
RC {ECO:0000313|Proteomes:UP000279833};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; UZAK01002151; VDO73417.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A183JHV6; -.
DR STRING; 6186.A0A183JHV6; -.
DR WBParaSite; SCUD_0000227901-mRNA-1; SCUD_0000227901-mRNA-1; SCUD_0000227901.
DR Proteomes; UP000050789; Unplaced.
DR Proteomes; UP000279833; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd11394; bHLHzip_SREBP; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR46062:SF1; LP12374P; 1.
DR PANTHER; PTHR46062; STEROL REGULATORY ELEMENT-BINDING PROTEIN; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000279833};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 15..68
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT COILED 51..85
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 335 AA; 37641 MW; 607A09A39F202B6C CRC64;
NKVNVEQCEQ KHETIKRAPH NAIEKRYRAS INGKIDELRR LLTPISSTDV KMNKSAVLRR
AIDRIRELEE RNAQLNTELM AFRSSNASNV SYVDSDKSTS ENELLSFETS PSLDNKKMND
YYHQCKTSPQ SFSSECIPSS INQVFHFTGK SIQPTNLSPY NSNGKGVSVK KMKEYSNSFH
SSSLSSASSS SLSSPPSINS PPNFQLNNDI KFITNSQYSS VSPPSSLSSS SPPLGISNGI
VIPSFILQHH DLYDNNCINN ENLPTHQQYQ YYHPLSSASL LQSSTTQNSY GSQQLFCTPH
STVILPEQSV MMKDDCTRKV HRKRLGLFKI QRLTF
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