ID   A0A183K6S5_9TREM        Unreviewed;       525 AA.
AC   A0A183K6S5;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Regulatory protein SIR2 homolog 7 {ECO:0000256|ARBA:ARBA00043038};
DE   AltName: Full=SIR2-like protein 7 {ECO:0000256|ARBA:ARBA00041832};
GN   ORFNames=SCUD_LOCUS10701 {ECO:0000313|EMBL:VDP41147.1};
OS   Schistosoma curassoni.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6186 {ECO:0000313|Proteomes:UP000050789, ECO:0000313|WBParaSite:SCUD_0001070101-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:SCUD_0001070101-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDP41147.1, ECO:0000313|Proteomes:UP000279833}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Dakar {ECO:0000313|EMBL:VDP41147.1}, and Dakar, Senegal
RC   {ECO:0000313|Proteomes:UP000279833};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the sirtuin family. Class IV subfamily.
CC       {ECO:0000256|ARBA:ARBA00038170}.
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DR   EMBL; UZAK01033939; VDP41147.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A183K6S5; -.
DR   STRING; 6186.A0A183K6S5; -.
DR   WBParaSite; SCUD_0001070101-mRNA-1; SCUD_0001070101-mRNA-1; SCUD_0001070101.
DR   Proteomes; UP000050789; Unplaced.
DR   Proteomes; UP000279833; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR003000; Sirtuin.
DR   InterPro; IPR026590; Ssirtuin_cat_dom.
DR   PANTHER; PTHR11085:SF1; NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-7; 1.
DR   PANTHER; PTHR11085; NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED; 1.
DR   Pfam; PF02146; SIR2; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   PROSITE; PS50305; SIRTUIN; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00236};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000279833};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00236}.
FT   DOMAIN          11..489
FT                   /note="Deacetylase sirtuin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50305"
FT   ACT_SITE        165
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         173
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         176
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         201
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
FT   BINDING         339
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00236"
SQ   SEQUENCE   525 AA;  59284 MW;  4095B89404E82221 CRC64;
     MSRNANTIQA SQDWHRDAAI LARLIKDNKG SIVIYTGAGI STSACIPDYR GTNGLWTVHS
     NRVTGVNSVL RTVGYNKNDQ ANYTEMLKLQ DKIRQCESRI KTPKKSKNTN LKLRLPEATI
     AKPTFTHMAI KVLVDEGYVR HVVSQNVDGL HVRSGLNREK LSELHGNLFI EQCIACEHTV
     FRTFDVAETT SRSHHYTGRI CPRCRNLHPV ESTIASDILK KTAEHSAVSK YKKNVSNENL
     MLSYRYAARK LAKSFEAVRL KAVEHLRNTQ KSEMLTDSVL TKAPLLRDVV VHFFERQPEM
     GLTEIYRIRS AIEAVHGRKV LQDAINATSN DRKPLNHGCK RSHEESTKYL IGSPWFKRMC
     PAMKMECQDF CKTSEAVDLK PISPDSLDTP AKLIVVVGSS LTVLRNYSFL WPYGLGRCGQ
     LSSSSKHKKK PTCVDSVFKP TSIPDTPENC RLVIINLQPT CKDVVADLVL RVPCDELFRV
     IMSDHLEIDV PQYDHRHDPL YSIGLSLSPE EECTRTRLNI PFSSV
//