ID   A0A183LEW6_9TREM        Unreviewed;      1104 AA.
AC   A0A183LEW6;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=Bile salt export pump {ECO:0008006|Google:ProtNLM};
OS   Schistosoma margrebowiei.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=48269 {ECO:0000313|WBParaSite:SMRZ_0000234001-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:SMRZ_0000234001-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A183LEW6; -.
DR   STRING; 48269.A0A183LEW6; -.
DR   WBParaSite; SMRZ_0000234001-mRNA-1; SMRZ_0000234001-mRNA-1; SMRZ_0000234001.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   CDD; cd18577; ABC_6TM_Pgp_ABCB1_D1_like; 1.
DR   CDD; cd18578; ABC_6TM_Pgp_ABCB1_D2_like; 1.
DR   CDD; cd03249; ABC_MTABC3_MDL1_MDL2; 1.
DR   Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011527; ABC1_TM_dom.
DR   InterPro; IPR036640; ABC1_TM_sf.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039421; Type_1_exporter.
DR   PANTHER; PTHR24221; ATP-BINDING CASSETTE SUB-FAMILY B; 1.
DR   PANTHER; PTHR24221:SF503; LP14331P; 1.
DR   Pfam; PF00664; ABC_membrane; 2.
DR   Pfam; PF00005; ABC_tran; 2.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS50929; ABC_TM1F; 2.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        75..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        182..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        536..556
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        576..597
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        661..681
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        687..704
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        761..783
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          5..211
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS50929"
FT   DOMAIN          212..445
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000259|PROSITE:PS50893"
FT   DOMAIN          540..826
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS50929"
FT   DOMAIN          860..1102
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000259|PROSITE:PS50893"
SQ   SEQUENCE   1104 AA;  120895 MW;  C8806CA17DFB6C75 CRC64;
     LPTVIFQSIL RQDVAWFDEQ SSGSLISKLS HNIDNIQLGL GSTLTDFMKN LSGFIVGIII
     NFAVGWKLAL VACAILPIIG AVFGCFGFLM KYFTRKEIVA YTRAGAVAGE VLEAIRTVVA
     FGGEKRELKR YREQLGTAEK AGLKKVVASG AVNGTIGLTV FCSTALLFWY GFKLIVNENY
     DAGAIVTIFV NVLLGSVFLG NALPSFQYFM NAQASATEIY SIIERVLKNF SLSIKSGQTV
     ALVGPSGSGK STVVHMLQRF YDPTKGEVLI EDEDIKNLDL KAYRNQIGCV QQEPVLFKGT
     ISDNIRLGKL DATQDEIEEA AKLANAHGFI QQLPDGYDTF VGERGGGMSG GQKQRIAIAR
     ALIRKPKLLL LDEATSSIDV KSERVVQMAL DRAIEGRTVV VVAHRLTTVR NANLIVVLDK
     GVVRESGTHA ELVAENGLYA AMLSNQRILE SAENDDSELL DEGSRNKYIV SGKDLLTKLD
     DICKMDNSED SVSETTGNVP YGNFSLISTI SILRNQKKNI KLSPTLRVLK LNRPELHLIV
     LGCICCVISG TTQPAFAILY TEMYSIFPLR SNPDLLFSRL TVVCGMMVVI GILRFLANVS
     QSLFFGKSGG ILVSRLRSKV FESMLNQEIG WFDKPENQAG ALTAKLANDA MKVTMYSGSQ
     LGFIIEAVAL IAMSFVVSFI YSWQLTLLIL AFYPLIVIGG FFQMRTLSGS SNIKNGNEAM
     RIAQEVTGSS YTVTAFTLED YFFKRFESHA VENLKNNLKT IFFNAIMYAI AESVLLFAVA
     AAYSLGAHLV STKAITVLAV FRVFVTIHLS AQSLGRTATL VLGTKAAGSA AKCILEILDR
     KPLISTNIGS VPREKFKGKI SFKNVNFKYF SQTERRVLKN FSHTIEPGQT VALVGPSGCG
     KSTLLQLVLR FYDPSYHGPD SGVFFDDINI RDIAPSWVRK QIGLVSQEPT LFDLTIRENI
     AYGDNSREVT MEEIIEAARA ANIHDFITTL PEQYETKVGQ RGSKLSGGQK QRIAIARALV
     RKPVLLVLDE ATSALDNESE RIVQEALDAA MGSRTSLVVA HRLSTVVNAD LVVVLRDERK
     IESGPPAALL AKKGAFYALH HMEN
//