ID A0A183LFW2_9TREM Unreviewed; 1429 AA.
AC A0A183LFW2;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Histone-lysine N-methyltransferase {ECO:0000313|WBParaSite:SMRZ_0000268601-mRNA-1};
GN ORFNames=SMRZ_LOCUS2687 {ECO:0000313|EMBL:VDO55707.1};
OS Schistosoma margrebowiei.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=48269 {ECO:0000313|WBParaSite:SMRZ_0000268601-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:SMRZ_0000268601-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDO55707.1, ECO:0000313|Proteomes:UP000277204}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Zambia {ECO:0000313|EMBL:VDO55707.1,
RC ECO:0000313|Proteomes:UP000277204};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; UZAI01000698; VDO55707.1; -; Genomic_DNA.
DR STRING; 48269.A0A183LFW2; -.
DR WBParaSite; SMRZ_0000268601-mRNA-1; SMRZ_0000268601-mRNA-1; SMRZ_0000268601.
DR Proteomes; UP000277204; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0043933; P:protein-containing complex organization; IEA:UniProt.
DR CDD; cd19171; SET_KMT2C_2D; 1.
DR Gene3D; 3.30.160.360; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR003889; FYrich_C.
DR InterPro; IPR003888; FYrich_N.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45888; HL01030P-RELATED; 1.
DR PANTHER; PTHR45888:SF6; HL01030P-RELATED; 1.
DR Pfam; PF05965; FYRC; 1.
DR Pfam; PF05964; FYRN; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00542; FYRC; 1.
DR SMART; SM00541; FYRN; 1.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS51543; FYRC; 1.
DR PROSITE; PS51542; FYRN; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000277204};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 882..990
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 1288..1404
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1413..1429
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 56..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1429 AA; 161950 MW; E768A232C0FB07F2 CRC64;
MTTVVDIFGS SNNSSTVSTN EVCQFSLISC SPNCDEDHLC NKNGLFISES VHDESFQRSP
SSFKTPSKEV SSPGSFELPS MPSDKSSSRD CSDGHCSVNF LISSDLTDTD HSNSACSLSP
CPQSVGHCSN ANDECSILYS DRMLESAFYR SVRTDISLDN RTNSHTFHPG FTDTQVSQDT
PFKTSYSCNK TSAFTSFGCN NLDNAHSFQY KNHNKSRGSD FQHLCETCIS SDKITTSNSS
PLKVCFSEAD YCFTEVIGCS AILGHSNAYP TSSTNCIRTS NSIVCFESQD LKSVYQNSQN
MYNHIQRRKS ACVSDASVPS NDGREFVYDR TEVQCSKVTN ITVPSVYLLK EVDSSMSGII
HNIVRDKFSN DDYTCDPEPI IMGSGKISTT SSLGKRSLNV CSSPTDLENS IHPIEPKQLS
PNYNYYLHKT PVISIAYPTN DRNKKPVLLQ ESIKNTDRKI SSQNLDLRHH WKSNATNSTT
KTNCFPVVEC QDSFGSKCKR KGSKILERGG KRHRSLNDKI RENISNHSPA DALIGPVFLQ
NANRYLQDPP LHHSFDLYPP IPSPRFPQNR FSGNYTNDVN IRGRKYFRFP LSLCKPACRP
IPDDIILRFL ARPDTEEKMN SLNHENFLSD AYKRTLSRNS YSNYISPSPL NQVSPLDLLT
SNQPCDMYTN GCITPPLYHT VSDKHSRGSG FITGHNSNQK YCEEVILCNR LNGEAHATCS
YCKMQIMLPQ RTFKWKSHDK ESYLPFCSSS CLARLKRQGP NCMTSFVPDA SNFDIPFTVT
STIESQPLII FLVKSNHPKR MKQSSKRLSS QDLQVNFKRS PNETSNRMLF GVSSTVKRWR
NIRWRRLIGS PPVCTFNVLR TSSDLPMSQK SFLSKKFSCI DTRVCQLCHQ IGDGSNDVTS
RLLNYNTDKW LHLNCILWCY ETYETVSGSL MDVPCSSEKA SKTPCTYCKN LGAGLPCFDS
DCQAVYHLPC AYQINCSFHP DRGMYCPLHL KSASNLPHLD SLAVERKVYV SRDEHSQVEK
VISDEDHFTS MQNVKEPKLK LRIGTLILHR IGQLLPEQLA SGVFHTSNFI YPVGYWTSRI
YWSFRHVGQR CRYDCRIEDS VRPDGVNQSL VDPILVKFTV EVIEPNEEKI FFEDTTCDGV
WRKIINRINS SRKCSSFFRI LQDNIQGEVL YGLTEPHIIR AIESLPGVDR LSNYLFKFGK
LQLIQEMPLA INPTGSARSE PKLRTYIRRK STGDVNTCPY IAHNHVFLEA PGHPYSSDIG
SPTYLNSLSP SMTSKSQQYR RLRWDWKTNV VLARSRIQGL GLYAARDISK STFIIEYLGE
VIRNEVANRR ERLYESQNRG IYMFRVDDDW IVDATMSGGL ARYINHSCDP NCTAEILNCD
NSNHIVIIAS KNIEKGDELT YDYKFDLEED RWDRIPCLCG SINCRKWMN
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