ID A0A183LWE0_9TREM Unreviewed; 1155 AA.
AC A0A183LWE0;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Integrin_alpha2 domain-containing protein {ECO:0000313|WBParaSite:SMRZ_0000811601-mRNA-1};
GN ORFNames=SMRZ_LOCUS8113 {ECO:0000313|EMBL:VDO79710.1};
OS Schistosoma margrebowiei.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=48269 {ECO:0000313|WBParaSite:SMRZ_0000811601-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:SMRZ_0000811601-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDO79710.1, ECO:0000313|Proteomes:UP000277204}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Zambia {ECO:0000313|EMBL:VDO79710.1,
RC ECO:0000313|Proteomes:UP000277204};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; UZAI01003429; VDO79710.1; -; Genomic_DNA.
DR STRING; 48269.A0A183LWE0; -.
DR WBParaSite; SMRZ_0000811601-mRNA-1; SMRZ_0000811601-mRNA-1; SMRZ_0000811601.
DR Proteomes; UP000277204; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF133; INTEGRIN ALPHA-PS2; 1.
DR Pfam; PF01839; FG-GAP; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 3.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 1.
DR PROSITE; PS51470; FG_GAP; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000277204};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 1132..1150
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 453..525
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 1030..1073
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1155 AA; 131985 MW; 07AF8710583541B8 CRC64;
MEVKRGELLQ LSSNSFSEQP IFRQFTVTNI SQEVKNSVDK ILKPNFPSEY NLFHWTTVTG
FKEIVNNTRV VWLIFGGSID RINLSSVNPF TKKAVGVIAC RLTYKSKYGL WLHLDECSPM
EVKNISNQEN EHDSKHHDGT TLLGVSLGSL EFKKPISGAV IVYCDPLWHT GEKKYRGQSV
VDMKYQEQAG GRCHIRLRHN GQWSHQRKTN QMEDIIQFCT NSGYSQPCGG GFSFDLQQTT
NVDITPHNNQ NYYDHLNSQL PNIRLLTSLF LANPGEVHIL DDILMNFKNI PDQQQDEFTV
HRILGNHVQF SQQVRWTPLS KSWKHYVNLE DNNSISGGDL WMHENLAIVS SLGDSYGPHI
KAFNPKSTEP EGLLVYSIIN KNRSNAESSG DFTGFGFTVE TVNIPQHSKD KSVSRTNYGI
LIGAPFDSST KQYNPNHGRV YIVCPEKRIT HKTGLFFVEG TRKNEFFGYS IARLGDVDGD
GIDDVAISAP AIQSKKMELP NGNLNISLYS GRVYIYRVTS QCTLDLQPLQ IIESPNPEIG
DGFGFGLSRG FDADGDGWPE FAVTSLKLNT VPYLFTMPKL LKSQCRVNIP PLYSMLHFKK
GTKIPFEINV RLYDLHLRQY INIPEGLIST KIRHHQVNPD VLWNDYLHSN GTTQLFSSDL
LIKQSVELST FDMFTIQLNK LKPRFQLGDK ISNIHLDSSQ SYILIKFHLI AMYGLEEMNL
NSIPLKISYK SELNLTECNF MQNLKKCNKQ EHPLIDWSEC SQLIQLAQPV CIPANECSSD
LSFKNISWSP IHSVMSTQSY KNSLTVVNNS FIKTIEYGHP NEQQQVIRLK LINLGPTKST
GLHILTRFYN WYLVDDENLT LTNGIQGKIT QINIKKLSKN ETSSINLINL TDSKIWTINI
DENGLFALIS LSPYLWIYPN EIIQIDIYVF IQGLLSLPTL STGQQLKSDI MSFSYSNMNY
RYPPKFEIQV TSETNDKQKE NNLVSISYRI LYKPMVNIFA GIQPSTIIDD RLEPHVIEQN
TISRKIFSYD IGPRIEHTFL IENQGWITLT NLSLILQIPY ETTNGHRLLY LTDQIREASY
TNQTTLLRNI LPTIIGSDGK QYGTCEIPRK FINPLDLTLM DFKFISTFKT KYFLLLYPLL
LILLKLLKYV NIRLM
//
