ID   A0A183LXJ0_9TREM        Unreviewed;       708 AA.
AC   A0A183LXJ0;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Cleavage and polyadenylation specificity factor subunit 2 {ECO:0000256|RuleBase:RU365006};
DE   AltName: Full=Cleavage and polyadenylation specificity factor 100 kDa subunit {ECO:0000256|RuleBase:RU365006};
GN   ORFNames=SMRZ_LOCUS8515 {ECO:0000313|EMBL:VDO81838.1};
OS   Schistosoma margrebowiei.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=48269 {ECO:0000313|WBParaSite:SMRZ_0000851601-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:SMRZ_0000851601-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDO81838.1, ECO:0000313|Proteomes:UP000277204}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Zambia {ECO:0000313|EMBL:VDO81838.1,
RC   ECO:0000313|Proteomes:UP000277204};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU365006}.
CC   -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. RNA-
CC       metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
CC       {ECO:0000256|RuleBase:RU365006}.
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DR   EMBL; UZAI01003720; VDO81838.1; -; Genomic_DNA.
DR   STRING; 48269.A0A183LXJ0; -.
DR   WBParaSite; SMRZ_0000851601-mRNA-1; SMRZ_0000851601-mRNA-1; SMRZ_0000851601.
DR   Proteomes; UP000277204; Unassembled WGS sequence.
DR   GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006378; P:mRNA polyadenylation; IEA:InterPro.
DR   Gene3D; 3.40.50.10890; -; 2.
DR   InterPro; IPR027075; CPSF2.
DR   InterPro; IPR025069; Cpsf2_C.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   PANTHER; PTHR45922; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2; 1.
DR   PANTHER; PTHR45922:SF1; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2; 1.
DR   Pfam; PF13299; CPSF100_C; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   3: Inferred from homology;
KW   mRNA processing {ECO:0000256|RuleBase:RU365006};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365006};
KW   Reference proteome {ECO:0000313|Proteomes:UP000277204};
KW   RNA-binding {ECO:0000256|RuleBase:RU365006}.
FT   DOMAIN          548..705
FT                   /note="Cleavage and polyadenylation specificity factor 2 C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13299"
FT   REGION          227..258
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          270..304
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        227..246
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        277..292
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   708 AA;  78074 MW;  92E9E0C6E20BE256 CRC64;
     MATSIIKLHT LSGAGDNGSP CYLLQPRRKD RDENLRQTIL KSLRRGGNVL IAVDTAGRCL
     EVAHFLEQCW LNQESGLMAY GLAMLNYVAL NVVDFAKSMV EWMSEKVVLS SLSDLSCGFS
     RQLFAEWADN DLNTVILTSQ ESVITGVDES SSQSLISRLI GLAKKDNDAR KDLPTSSTGT
     SILPLTLSQR VSCSQADQSG SDIPHLKNSA KGFSFSQNTN STISDACDEL NSETEPGNTS
     ASYTDIPMPS AGDITHSDVS PQITEGIIEK QPSCDSELEN ESTCGSNRPY SSEEGTHVEK
     SKSLSLTLSV TRDHSKKTIV PSNTTRLFPK TSLPLNMEQF GVTNLHLTSG RHQAGYDIYP
     GLHNQAGGQF FRVAKRTQLL FPQNEKKIHW DEYGAHLDPE LFTSTEPVSS QAALPNWDIK
     SKDTKTNSDI VSSGFSSTSI LDYLVARTPT FDVLDSNTRC VTHHLEIPLR CEVVFLDYEG
     RSDGEAMKRI LIGLRPQEII LVGNNAPAID HLANYCRGVM LLDPNYIHIP HPREIVNCTK
     EGDIYQARMK DSLVSSLKFT KIRDYELAWV EATVSLDDKS DYHIKEKNNN NAENNCNNDS
     GDVEMSTGNN LELKSRTPLA ADQLPVLSLP TGPIGQHKTV FVNEPKLSDL KQLLLSQGLM
     AEFVSGILVV DNCVAIKRSE AGKLLLEGLL CGTYFEVRRI LYQQFAIL
//