ID   A0A183M5M8_9TREM        Unreviewed;       661 AA.
AC   A0A183M5M8;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=TOP4c domain-containing protein {ECO:0000313|WBParaSite:SMRZ_0001135401-mRNA-1};
GN   ORFNames=SMRZ_LOCUS11355 {ECO:0000313|EMBL:VDO94941.1};
OS   Schistosoma margrebowiei.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=48269 {ECO:0000313|WBParaSite:SMRZ_0001135401-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:SMRZ_0001135401-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDO94941.1, ECO:0000313|Proteomes:UP000277204}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Zambia {ECO:0000313|EMBL:VDO94941.1,
RC   ECO:0000313|Proteomes:UP000277204};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the type II topoisomerase family.
CC       {ECO:0000256|ARBA:ARBA00011080}.
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DR   EMBL; UZAI01006339; VDO94941.1; -; Genomic_DNA.
DR   STRING; 48269.A0A183M5M8; -.
DR   WBParaSite; SMRZ_0001135401-mRNA-1; SMRZ_0001135401-mRNA-1; SMRZ_0001135401.
DR   Proteomes; UP000277204; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00187; TOP4c; 1.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 3.30.1490.30; -; 1.
DR   Gene3D; 3.40.50.670; -; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR013759; Topo_IIA_B_C.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   InterPro; IPR001154; TopoII_euk.
DR   InterPro; IPR031660; TOPRIM_C.
DR   PANTHER; PTHR10169:SF38; DNA TOPOISOMERASE 2; 1.
DR   PANTHER; PTHR10169; DNA TOPOISOMERASE/GYRASE; 1.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   Pfam; PF16898; TOPRIM_C; 1.
DR   PRINTS; PR01158; TOPISMRASEII.
DR   PRINTS; PR00418; TPI2FAMILY.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000277204}.
FT   DOMAIN          167..643
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
SQ   SEQUENCE   661 AA;  76595 MW;  2B7228BF37B6C3D9 CRC64;
     SGWLVVSFHL CDLICFDQDG SHIKGLIINF VHCNWPNLLK HNVVEEFITP IVKVFKGKQE
     YSFYSLPEFE EWQKSTPNWH TWRVKYYKGL GTSTSKEAKE YFSDMNRHRI RFRYSGTEDD
     GSIQLAFDKS KIADRKNWLT NFTQERKRRR ELGLPEPYLY GKDTRAITYH DFVHKELVLF
     SNLDNERSIP SVVDGLKPGQ RKVLFTCLKR NLIREIKVAQ LAGSVAELSA YHHGEQSLMS
     TIIGLAQNFV GSNNLNLLQP IGQFGTRLSG GKDAASPRYI FTALNSLTRL IFHLEDDPLL
     NYLYDDNQRI EPEWYAPIIP MVLVNGADGI GTGYATHILN YNVIEIINNL YRMLDGEEPH
     RMLPNFRGFT GTIEDLGNNR YVCYGEVAVL DDDTLEITEL PIRVWTQNYK ESVLEPMLNG
     SEKVPACITD YKEYHTDVTV RFVVKMSPEK LREAESNGLH KFFKLQTVMS TGSMVCFDPL
     GCLKCYPNEM VIIREFYELR LTWYEKRKVY LEGVLSAEAR KLENQARFVL EKIQSIMVIE
     NKPKKELIRM LKEANYDSDP VKAWKESIDK AAAVQEQEEA RAEEGVPQTE AVEAGQPDYN
     YILNMPLWSL TKERKDDLLA QRDSKQKELL ILKSKSPSDL WREDLKKLEE EYKVFSYLII
     L
//