ID A0A183MS68_9TREM Unreviewed; 1087 AA.
AC A0A183MS68;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
GN ORFNames=SMRZ_LOCUS18893 {ECO:0000313|EMBL:VDP29616.1};
OS Schistosoma margrebowiei.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=48269 {ECO:0000313|WBParaSite:SMRZ_0001889401-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:SMRZ_0001889401-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDP29616.1, ECO:0000313|Proteomes:UP000277204}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Zambia {ECO:0000313|EMBL:VDP29616.1,
RC ECO:0000313|Proteomes:UP000277204};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; UZAI01017795; VDP29616.1; -; Genomic_DNA.
DR STRING; 48269.A0A183MS68; -.
DR WBParaSite; SMRZ_0001889401-mRNA-1; SMRZ_0001889401-mRNA-1; SMRZ_0001889401.
DR Proteomes; UP000277204; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 3.30.300.320; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 10.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR035993; Notch-like_dom_sf.
DR InterPro; IPR000800; Notch_dom.
DR PANTHER; PTHR24033; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24033:SF151; PROTEIN EYES SHUT; 1.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF00066; Notch; 2.
DR PRINTS; PR01983; NOTCH.
DR SMART; SM00181; EGF; 13.
DR SMART; SM00179; EGF_CA; 3.
DR SMART; SM00004; NL; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 6.
DR SUPFAM; SSF90193; Notch domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 11.
DR PROSITE; PS01186; EGF_2; 8.
DR PROSITE; PS50026; EGF_3; 7.
DR PROSITE; PS01187; EGF_CA; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000277204};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 35..72
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 95..151
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 153..206
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 208..244
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 335..377
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 379..420
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 422..459
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 62..71
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 141..150
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 196..205
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 234..243
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 367..376
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 391..408
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 410..419
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 449..458
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1087 AA; 122921 MW; CD4F4A71F2EE93CB CRC64;
MTTNENIEMI NESNDLFVCL CPEGFHGKLC ETKIINNYCT EIVCQNGGQC NILDNGKEYC
TCLKNYHGLY CEVEENQEEQ NTELFRIEKD QSEMETFNCF KTPCSNNGTC HVLGDISKSS
TITITNTTVN NNNSGSTFCH CKPGFSGHYC ENIQDYCQHS PCRNGGVCML NNGNNNNNTI
NHLNVVTAES NYTCMCQPGY SGKHCEINIF DCFNQPCGSY GICKDDINGY HCECLRGWEG
LHCDKKSLST KLVTYEKNTG SNSMLVLMNS NSQEFHFNHS RLCPKNYYCA NSALCIFTND
DTSSFMLNNL NIASEYKCLC ETAIGRFEGN HCDIDVNECF ESEEKQSSLC QNGGQCINTY
GSYICSCTTE YYGKHCEYLF NPCNIDNTSI CFNGGVCLPS SDGIGTLCVC PKGFTGPQCR
EQINECIGHH SCMNDGICLD LIGKYHCLCP TGRYGMNCEL TSKQICTNQS CSENVNVRNC
TTNLCLNGGL CTNYYTINND SVQRDNQHHK YLRIFEQNNL LESQLVHCSC PFGYIGEYCQ
IELDFCQLFH HIKHYFFNYF KQPKEIEDYF LKNVIISSYH INDWLISSSL SSLYHSWYEI
NLLYSTFVIN YTYSRLLNDT NIRKILSTGN LFINDSLVDR KSTLSDSTLF MITSPMGLCD
PIGSSQCVPL LSSVSDGLRS DSGGFTCICH VDYEGRYCEK YVDFCDKMNK QYNGNYCLNG
GWCENQIKQI TPSYNSDHNN YNKTHRHRIF PICHCPSGFG GERCEVYHEL CIHSPCLNGG
TCHPNKQQLS HLQLKEIKFN STVSGNNSSS YFIPPYRCEC LFGWSGIHCE VSTGLYCDVS
RLCMDYTNCN DSLTFNCPCT KPGYCGLNCD KYGTECFVFT NTSSSIVNEI TTDLPIATTV
FTTTTTISST NIVTSNNIKK HKTKSNVTLW PGEETELSYC LRENCQLKKH NGRCDRECDL
IACDFDHGDC LYALSVPLNP LSYIEPLESN DISNHDDNNT THYMSFVQDI QQHPEPAIPW
RSCSVLIEHT EHTPCHLLFG DGNCDPQCFR EECLFDGWDC IHTKFDVNLT KVGSFSLKLI
IIIMSVN
//