ID   A0A183MVR9_9TREM        Unreviewed;      1296 AA.
AC   A0A183MVR9;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Titin {ECO:0008006|Google:ProtNLM};
GN   ORFNames=SMRZ_LOCUS20144 {ECO:0000313|EMBL:VDP34427.1};
OS   Schistosoma margrebowiei.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=48269 {ECO:0000313|WBParaSite:SMRZ_0002014501-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:SMRZ_0002014501-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDP34427.1, ECO:0000313|Proteomes:UP000277204}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Zambia {ECO:0000313|EMBL:VDP34427.1,
RC   ECO:0000313|Proteomes:UP000277204};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; UZAI01018196; VDP34427.1; -; Genomic_DNA.
DR   STRING; 48269.A0A183MVR9; -.
DR   WBParaSite; SMRZ_0002014501-mRNA-1; SMRZ_0002014501-mRNA-1; SMRZ_0002014501.
DR   Proteomes; UP000277204; Unassembled WGS sequence.
DR   CDD; cd00063; FN3; 3.
DR   CDD; cd00096; Ig; 2.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 12.
DR   InterPro; IPR045609; DUF6451.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   PANTHER; PTHR14340:SF24; -; 1.
DR   PANTHER; PTHR14340; MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3; 1.
DR   Pfam; PF20049; DUF6451; 1.
DR   Pfam; PF00041; fn3; 2.
DR   Pfam; PF07679; I-set; 8.
DR   SMART; SM00060; FN3; 2.
DR   SMART; SM00409; IG; 8.
DR   SMART; SM00408; IGc2; 7.
DR   SUPFAM; SSF49265; Fibronectin type III; 2.
DR   SUPFAM; SSF48726; Immunoglobulin; 9.
DR   PROSITE; PS50853; FN3; 3.
DR   PROSITE; PS50835; IG_LIKE; 7.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000277204};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          9..101
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          103..195
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          366..455
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          470..548
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          552..637
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          642..727
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          974..1067
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          1073..1165
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          1169..1256
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          1265..1296
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   REGION          289..329
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1276..1296
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        304..319
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1296 AA;  147142 MW;  F1496647151C4C10 CRC64;
     NQKQAGKGPV FEKPKIYQNN LGRDVILECR CSADPAPTFT WYQNTKELKA RPGRYEMEES
     KDGAVFLNKL KIINFMNADA GTYKLMAKNN SGDATAVMEV KMPKIVGMPN IRFEDNNQRA
     FLEVRVDSGN PPEAKWSHSG KSIKVEGRYS SECTMEGRNY VMNLTINDLT EKDSGLYECE
     IFNGVGKVQQ SITVKVPRRT FIMTVDYAVG SVTPQAKVLK NGIDLSLDKR CTIRVDSTKH
     SVIITIKNVQ IDDKSTYTLQ LLANGNVCDK GNFDLSVIQV NDEANEEVDE VGELHVPSNK
     GSRRSSTVKK EEEYLNRRSS QEKPGLLDPK ALEQSLQARR DSMTNRRTSL ADAIPGFAGL
     KHRETPKVEK EYFVEELQDV KIKEGSLKAL LKCTFCKSTS KFRWYKNKLE IFQGPKYNFL
     QEGNEFALEI KKIAMEDVGK YTCKCNDIST TCTIQVEEKK HTYHFNQKLP KTAEVVRGKD
     LTVECSVSDP RATVAWYHKG EKVEYVAGKI EIKRRENRCI LRIVRARPEQ EGEYCCIVEG
     DETYMDIAVE DPDWSFTREL KPQQALENDE VVTFECEVSD RDAEVTWYKN GEPITANDKY
     EMLAEKKVKR ILKVKKITMT DDAEYTCKVA KKTTTATCTV KPDVEFRQNL IDTKGIETKH
     KELECRAFNP KKYPVYWFKD GLPIELNDRI STTEIEGSLY LIFQYLEMDD TGYYSCKIGN
     HETKGLLEVQ ECEKPPSVDL TNFKSQATLK KGANFMTAVP FKVRIFNTNV KAVLLYGAET
     WGTTTTTIKK VQVFINSCLR KILNIHWPDT IISSVLWERT NQLPAEEEIR KRRWKWIEHT
     LSKSSNCITS QALVTWNSEG KRKRGRPKNT LHRIIEADMK RMNNNWKELE RIAQNRVGWR
     MMVGFPVPQV VLMCNGEPVN EAIKLKPVVK GNIVELQLED AARADSGKYE LKLKNELGEA
     SVPLELNILD RPGKPRGPLL LTSLSAKKCV LEWDPPEDDG GSPIKHYVVE KMDVSDGNWK
     LVKNAKAPQC EVDLEEGHKY KFRVRAVNNE GESENLEVDK EILARDVCDP PDAPTGLEIE
     DYDRDHAKLK WLPPRRDNGA PVLKYILEAK AKSKNKWETV KEVSDPAAKV DLKEGEEYEF
     RVTAVNKAGK SEPSEVSKPL IAKPRFLKPF IIKTGLKPIK VKVGEVVQLK LDFRGEPDPV
     AVWSKESTPL ESTPEIELTF ELRSASLKIL SAQRKDTALY TLRVSNEVGE DQASIEVVAL
     GKPSRPVPPM EITEVTKNSA QLSWKKPEDD GGTPIT
//