ID   A0A183MW49_9TREM        Unreviewed;       366 AA.
AC   A0A183MW49;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=MPN domain-containing protein {ECO:0000313|WBParaSite:SMRG1_62480.1, ECO:0000313|WBParaSite:SMRG1_62480.2};
GN   ORFNames=SMRZ_LOCUS20274 {ECO:0000313|EMBL:VDP34970.1};
OS   Schistosoma margrebowiei.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=48269 {ECO:0000313|WBParaSite:SMRZ_0002027501-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:SMRZ_0002027501-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDP34970.1, ECO:0000313|Proteomes:UP000277204}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Zambia {ECO:0000313|EMBL:VDP34970.1,
RC   ECO:0000313|Proteomes:UP000277204};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the peptidase M67C family.
CC       {ECO:0000256|ARBA:ARBA00010981}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; UZAI01018246; VDP34970.1; -; Genomic_DNA.
DR   STRING; 48269.A0A183MW49; -.
DR   WBParaSite; SMRG1_62480.1; SMRG1_62480.1; SMRG1_62480.
DR   WBParaSite; SMRG1_62480.2; SMRG1_62480.2; SMRG1_62480.
DR   WBParaSite; SMRG1_62480.3; SMRG1_62480.3; SMRG1_62480.
DR   WBParaSite; SMRZ_0002027501-mRNA-1; SMRZ_0002027501-mRNA-1; SMRZ_0002027501.
DR   Proteomes; UP000050790; Unassembled WGS sequence.
DR   Proteomes; UP000277204; Unassembled WGS sequence.
DR   GO; GO:0061578; F:K63-linked deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR   CDD; cd08066; MPN_AMSH_like; 1.
DR   Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR   Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR   InterPro; IPR000555; JAMM/MPN+_dom.
DR   InterPro; IPR037518; MPN.
DR   InterPro; IPR044098; STAMBP/STALP-like_MPN.
DR   InterPro; IPR015063; USP8_dimer.
DR   PANTHER; PTHR12947; AMSH-LIKE PROTEASE; 1.
DR   PANTHER; PTHR12947:SF13; FI19924P1; 1.
DR   Pfam; PF01398; JAB; 1.
DR   Pfam; PF08969; USP8_dimer; 1.
DR   SMART; SM00232; JAB_MPN; 1.
DR   SUPFAM; SSF102712; JAB1/MPN domain; 1.
DR   PROSITE; PS50249; MPN; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000277204};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          197..326
FT                   /note="MPN"
FT                   /evidence="ECO:0000259|PROSITE:PS50249"
SQ   SEQUENCE   366 AA;  41868 MW;  E9DB1EC73996627A CRC64;
     MNQTPQERLD ALLKSAEDFT IIQNIDISHY ARFIRSMFRL SVQFSEAGQK ERAYILSIRA
     VLCIRELPNH NGYQRLDPRV QNELKSLGKL LPKSAEFLKD DLKKKYTEEY ELYKKSLSIT
     EWKVNTNGPV IPFLDHSSKP YDDYPVDPNS YRLSLSNLSS VNGTLYPAFN KAFNYTLDEL
     PKSLYSNYAG NYGLTKTYLS RHLISDFLNL ASKNTKGNRE TCGTLCGKLI SGNFYITNLL
     IPKQSGTPDS CVTYKEEEIF EYLDRRQLIT LGWIHTHPTQ TAFLSAVDLH CQLSYQTMLP
     EAIAIVCAPK FDDIKCFSLT PDHGISFLSK CKKTGFHPHA TDLPLYEQSQ HVIFDDTVEH
     SSDDLR
//