ID A0A183MY21_9TREM Unreviewed; 544 AA.
AC A0A183MY21;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=heparosan-N-sulfate-glucuronate 5-epimerase {ECO:0000256|ARBA:ARBA00012087};
DE EC=5.1.3.17 {ECO:0000256|ARBA:ARBA00012087};
GN ORFNames=SMRZ_LOCUS20946 {ECO:0000313|EMBL:VDP37678.1};
OS Schistosoma margrebowiei.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=48269 {ECO:0000313|WBParaSite:SMRZ_0002094701-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:SMRZ_0002094701-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDP37678.1, ECO:0000313|Proteomes:UP000277204}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Zambia {ECO:0000313|EMBL:VDP37678.1,
RC ECO:0000313|Proteomes:UP000277204};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[heparosan-N-sulfate](n) = [heparan-N-sulfate](n);
CC Xref=Rhea:RHEA:20197, Rhea:RHEA-COMP:9556, Rhea:RHEA-COMP:9557,
CC ChEBI:CHEBI:58041, ChEBI:CHEBI:58287; EC=5.1.3.17;
CC Evidence={ECO:0000256|ARBA:ARBA00000434};
CC -!- PATHWAY: Glycan metabolism; heparin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004841}.
CC -!- SIMILARITY: Belongs to the D-glucuronyl C5-epimerase family.
CC {ECO:0000256|ARBA:ARBA00005584}.
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DR EMBL; UZAI01018512; VDP37678.1; -; Genomic_DNA.
DR STRING; 48269.A0A183MY21; -.
DR WBParaSite; SMRZ_0002094701-mRNA-1; SMRZ_0002094701-mRNA-1; SMRZ_0002094701.
DR UniPathway; UPA00862; -.
DR Proteomes; UP000277204; Unassembled WGS sequence.
DR GO; GO:0047464; F:heparosan-N-sulfate-glucuronate 5-epimerase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:InterPro.
DR GO; GO:0030210; P:heparin biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR010598; C5-epim_C.
DR InterPro; IPR039721; C5-epimerase.
DR PANTHER; PTHR13174; D-GLUCURONYL C5-EPIMERASE; 1.
DR PANTHER; PTHR13174:SF3; D-GLUCURONYL C5-EPIMERASE; 1.
DR Pfam; PF06662; C5-epim_C; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000277204}.
FT DOMAIN 311..477
FT /note="D-glucuronyl C5-epimerase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06662"
SQ SEQUENCE 544 AA; 62851 MW; 57BD2C152820419B CRC64;
ESQLICVFTF KYKQSCILGV PISQQWSSRG YPYPIQIAQF GLNHFSQLVI SSGQAKFENV
RNVLSLDNKN MELDLIVPSN NVIHRWADKE FIHKWNDRLM LSVDKLNFYG QVLSIIPKLQ
EWDYLIMIGR QWTYGSHIEL SLLWYPPGGS YKNYPTKSLI VYNCSSSPSR HQTYATIIHN
NKVTYWMPEC EKQAKIYGFV DNIKIARDLY TDLMKVFYAN RKSSEYTGLS SMKLLNTVND
TNNPSHVQVL NINFYINAKY NTNDIIIEKL YLGKLTNLQL TFPTVNRINL AEKLFHEIRF
ISAADWFIKH QDKKTGGWSV NVQRSLNGRK ALKPGWYSAM GQGQAISLLV RTYNYTGNPL
YLEACHRALD LFSVNINHGG IRSYFLNQSD LVWFEEYPFD PPIHILNGFI YSLIGLYDYT
KLLVNSSDPL TLSYLSKAQN YLDIGLTSLS KLLPLFDSGS GSFYDLRHLS TAYNNKPVKQ
SRSKFSKSSF QLSTGPNRAR WSYHSVHIKQ LQTLVDLDPK HAIQWNTTAN RWIAYLQGFR
SLQN
//
