ID   A0A183N115_9TREM        Unreviewed;       759 AA.
AC   A0A183N115;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=GATOR complex protein NPRL3 {ECO:0000256|RuleBase:RU368069};
DE   AltName: Full=Nitrogen permease regulator 3-like protein {ECO:0000256|RuleBase:RU368069};
GN   ORFNames=SMRZ_LOCUS21990 {ECO:0000313|EMBL:VDP41495.1};
OS   Schistosoma margrebowiei.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=48269 {ECO:0000313|WBParaSite:SMRZ_0002199101-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:SMRZ_0002199101-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDP41495.1, ECO:0000313|Proteomes:UP000277204}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Zambia {ECO:0000313|EMBL:VDP41495.1,
RC   ECO:0000313|Proteomes:UP000277204};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: As a component of the GATOR1 complex functions as an
CC       inhibitor of the amino acid-sensing branch of the TORC1 pathway.
CC       {ECO:0000256|RuleBase:RU368069}.
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|RuleBase:RU368069}.
CC   -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000256|ARBA:ARBA00010546,
CC       ECO:0000256|RuleBase:RU368069}.
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DR   EMBL; UZAI01018942; VDP41495.1; -; Genomic_DNA.
DR   STRING; 48269.A0A183N115; -.
DR   WBParaSite; SMRZ_0002199101-mRNA-1; SMRZ_0002199101-mRNA-1; SMRZ_0002199101.
DR   Proteomes; UP000277204; Unassembled WGS sequence.
DR   GO; GO:1990130; C:GATOR1 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0034198; P:cellular response to amino acid starvation; IEA:UniProtKB-UniRule.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR   InterPro; IPR005365; Npr3.
DR   PANTHER; PTHR13153; CGTHBA PROTEIN -14 GENE PROTEIN; 1.
DR   PANTHER; PTHR13153:SF5; GATOR COMPLEX PROTEIN NPRL3; 1.
DR   Pfam; PF03666; NPR3; 1.
PE   3: Inferred from homology;
KW   Lysosome {ECO:0000256|RuleBase:RU368069};
KW   Reference proteome {ECO:0000313|Proteomes:UP000277204};
KW   Signal {ECO:0000256|RuleBase:RU368069}.
FT   REGION          619..641
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   759 AA;  84678 MW;  06F38C6B302361C6 CRC64;
     MFFNESSFGN VPITAGLNQN FMGSADRTLN NCPTICSNIN SSLCTTSSLS PSNPVGGVTT
     NLSNPNIVLG SLYSTDPSLQ VPSTESPLIG NLGISNIEGI PANVLLSLLH QQTQALQRKI
     YIKLDHNIFI GAAFNLSPSD IETIGLIEDT EDCNTKICDN ELSRTTMISF TVGFLMDSSA
     PPSVLSYLTE LSRLIGSQVR RAELVFNYLR DQRDIIVSTL EKYSYADTNS WSGNLTTDYN
     TNKYGPDNLN FSKSSQFFSN KRYIKIAESS NSDRDTNFVS SVMDQECNES KLPNALNANQ
     SINENISANN SYNNSDDFHD KMNDVTTMNP LEKLVQISSL CAELKSILDS VCKTGHVNVK
     INKIYPVCFC LPHKAYCLNN NDGISNCIVA VRPMAIWNAM DKIRPYHALI LLLRKSDLLR
     DYLPTDINPT LKDFINALSP TISLYNLAQR FHSQSHCLNL ALWLIYRGHA LIVYPIVANN
     MYILAPHSKA WFTPQLIGQF ATSFPDVNFA ELLTSFSTSF ILKDHFDSSD SIVDNLHYDG
     DSDVVRNRSS KTSWTNLPLT EKINLIAWLL RRRLIIQIHL YIFPTFLSNN NVSETNMFND
     IKNISKHFEG VHVSNNSVNS TIHSSSNSSS EYDSDETTSE IKGSNNLGVD STILNLDELC
     KKIPKDVLCE LTNNLPVESQ QTLLLSILSH PGAIQNISLL RLFGRILPHL PAHLEEIMFK
     EQIKRSTLVE CIERFAPFLA TARLPDPVTS CFAGIPWPN
//