ID   A0A183N3I6_9TREM        Unreviewed;       936 AA.
AC   A0A183N3I6;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Dynein heavy chain coiled coil stalk domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=SMRZ_LOCUS22861 {ECO:0000313|EMBL:VDP44908.1};
OS   Schistosoma margrebowiei.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=48269 {ECO:0000313|WBParaSite:SMRZ_0002286201-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:SMRZ_0002286201-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDP44908.1, ECO:0000313|Proteomes:UP000277204}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Zambia {ECO:0000313|EMBL:VDP44908.1,
RC   ECO:0000313|Proteomes:UP000277204};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC       {ECO:0000256|ARBA:ARBA00008887}.
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DR   EMBL; UZAI01019378; VDP44908.1; -; Genomic_DNA.
DR   STRING; 48269.A0A183N3I6; -.
DR   WBParaSite; SMRZ_0002286201-mRNA-1; SMRZ_0002286201-mRNA-1; SMRZ_0002286201.
DR   Proteomes; UP000277204; Unassembled WGS sequence.
DR   GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   Gene3D; 1.20.920.20; -; 1.
DR   Gene3D; 1.20.920.30; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR041589; DNAH3_AAA_lid_1.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR   PANTHER; PTHR46961:SF9; DYNEIN HEAVY CHAIN, CYTOPLASMIC-LIKE PROTEIN; 1.
DR   Pfam; PF12775; AAA_7; 1.
DR   Pfam; PF12780; AAA_8; 1.
DR   Pfam; PF17857; AAA_lid_1; 1.
DR   Pfam; PF12777; MT; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000277204}.
FT   DOMAIN          118..207
FT                   /note="Dynein heavy chain 3 AAA+ lid"
FT                   /evidence="ECO:0000259|Pfam:PF17857"
FT   DOMAIN          275..527
FT                   /note="Dynein heavy chain AAA module D4"
FT                   /evidence="ECO:0000259|Pfam:PF12780"
FT   DOMAIN          541..887
FT                   /note="Dynein heavy chain coiled coil stalk"
FT                   /evidence="ECO:0000259|Pfam:PF12777"
FT   COILED          785..833
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   936 AA;  106814 MW;  8D810CD69A31FC4D CRC64;
     MGKKIIVFVD DLNMPVRETY GAQPPIELLR QWLDHWNWYD LKTNEAIRLI DLLFIGSMGP
     PGGGRNVITP RFLRHLNIVT VNEFDDHTMK TIFTRIMDWH ITVKDFSPDY KKIPEQIVNA
     TLEVYKAALQ NLLPTPTKSH YLFNLRDFSR VIQGILLSVP ESAETLDSMK RLWVHEVFRV
     YYDRLVDDAD REWLFNFIRQ CVKTHLDVEF NTLFQHLTGD NETEVTEDHL RSLMFCDFAD
     PKGKRNYAEV NDVEQLRKVT EAYLEEYNQL SKKPMNLVLF RFAIEHVCRI ARILKQPRSH
     ALLVGIGGSG RQSLTRLAAH LSDFDLFQVE ISKSYGVNEW KEDLKHILRK SSETDNHAIF
     LFTDTQIKQE SFLEDINNLL NAGEVPNLYA IDEKMELCEK IRQIDRARDR NKQTDGSPVA
     LFNYFIQRVR EQLHIVLALS PIGDSFRNRL RKFPSLAWPE DALTAVATRS LKDIDMTDEI
     RNGCIDLCKY FHTSTCNLST RFLLELDRHN YVTPTSYLEL ITTFITLLSK KRTEVLTQKS
     RYEVGLEKLS SAANEISLMS VELQSLQPKL VQASKEVDEV MIVVEQQSAE AAKQEKLVRV
     DEAVAGEQAK AAETMKEECD NDLAEAIPIL ESALKALETL TPADITIVKT MKSPPAGVRL
     VMEAVCVLKG IKPDRINDPS GSGKKIEDFW GPSKKLLGDM KFLENLKNFD KDNIPLTIMK
     TIRERYIPNP DFKPERVAVA STACEGLCKW VIAIERYDIV AKIVAPKKEA LAKAMSEYNI
     AMNALNIKRA ALKEVQDRLK LLTDDLEMNK RKKIDLENKV DLCTKKLERA EQLIGGLGGE
     KSRWTDAAKS LGKQYINLTG DILISSGLVA YLGAFTSTFR QIQVKIWLNE IMKYSIPCSE
     SFSLVHTLGN PVDVRAWNIA GLPTDDFSIE NGIIMA
//