ID   A0A183P1K4_9TREM        Unreviewed;       802 AA.
AC   A0A183P1K4;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=DNA_mis_repair domain-containing protein {ECO:0000313|WBParaSite:SMTD_0000823901-mRNA-1};
GN   ORFNames=SMTD_LOCUS8240 {ECO:0000313|EMBL:VDP43677.1};
OS   Schistosoma mattheei.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=31246 {ECO:0000313|WBParaSite:SMTD_0000823901-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:SMTD_0000823901-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDP43677.1, ECO:0000313|Proteomes:UP000269396}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Denwood {ECO:0000313|EMBL:VDP43677.1}, and Denwood, Zambia
RC   {ECO:0000313|Proteomes:UP000269396};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|ARBA:ARBA00006082}.
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DR   EMBL; UZAL01028784; VDP43677.1; -; Genomic_DNA.
DR   STRING; 31246.A0A183P1K4; -.
DR   WBParaSite; SMTD_0000823901-mRNA-1; SMTD_0000823901-mRNA-1; SMTD_0000823901.
DR   Proteomes; UP000269396; Unassembled WGS sequence.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR032189; Mlh1_C.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF16413; Mlh1_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000269396}.
FT   DOMAIN          243..418
FT                   /note="DNA mismatch repair protein S5"
FT                   /evidence="ECO:0000259|SMART:SM01340"
SQ   SEQUENCE   802 AA;  89413 MW;  B518C6FF1AD2CFAE CRC64;
     MDKLNSDDSS KSSANLLLLS PDKSMPQTIK RLPKEVINRI AAGEVIQRPV NAIKELLENS
     IDAGSTMIKI TVKDGGLKLI QVQDNGCGIH QSDLPILCER FTTSKLKEFS DLSKISTFGF
     RGEALSSLSH VALVTVTTRT ANQNCAFKVK YRAGVAESKP VPCAGNPGTT IVAENLFYNA
     PIRKSALKNG REELSKVTDV VAQYAIHYAQ QCGFHLHSES ATGKSSIEQD LRTSAGWSRM
     DAIRAVIGSS IEQNLISFTS SQCSSSESTR LAIERYGLRY EGLLTAPNQV SSGKLLFLYG
     CSPSLKLNLF INNRLVSCTP IKRIVECAYS SVISRGLSSN SIDQHQAILT TKKSFKVSTN
     SNIMYKSSTF NSLYVYLNIQ LPAHTLDVNV HPTKAEVNFL HEDEIVNGLQ DAIEQALLSS
     AQIQTFIRNC LPTPTTFKSL KDLNIHNDQS IDNNSKDLHS SQVVYRPNEK VRIDLREQQL
     ERFLSPQSNY MNNNDNNMVC SKLERLHNNS LKKSIGEMSP DIEVDSDEAD EILKSNLLQE
     NSSLNYDEFD WNKATTEQSH LFHDQKEKDS DENELTTTAQ NHLKSYTNNN ATINNNDTTV
     SLTSRPIIKT DASLSSQNTT TTNSLLSKSN TLLTYSNNDM IESVSSKPRH RTVYLMSILA
     LKRNLECDLD QSIKTTLRSC KFIGFIDETR CLTQHHTELL LIRLKPLSQA LFYQLLLTNF
     GNHGEIILRE PAPLADLLSI GHEYLRKSSR YLSNISSDEF IKKATATLVQ HASMLWDYFS
     IKITTDSNGN QVLTGIPLII AK
//