ID   A0A183QSA5_9TREM        Unreviewed;      1055 AA.
AC   A0A183QSA5;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=GPN-loop GTPase 2 {ECO:0000256|ARBA:ARBA00014588};
DE   AltName: Full=ATP-binding domain 1 family member B {ECO:0000256|ARBA:ARBA00029700};
OS   Schistosoma rodhaini.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6188 {ECO:0000313|WBParaSite:SROB_0000655201-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:SROB_0000655201-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
CC   -!- FUNCTION: Small GTPase required for proper localization of RNA
CC       polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly
CC       step prior to nuclear import. {ECO:0000256|ARBA:ARBA00003181}.
CC   -!- SIMILARITY: Belongs to the GPN-loop GTPase family.
CC       {ECO:0000256|ARBA:ARBA00005290}.
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DR   STRING; 6188.A0A183QSA5; -.
DR   WBParaSite; SROB_0000655201-mRNA-1; SROB_0000655201-mRNA-1; SROB_0000655201.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:InterPro.
DR   GO; GO:0006457; P:protein folding; IEA:InterPro.
DR   CDD; cd17871; GPN2; 1.
DR   Gene3D; 1.10.1410.10; -; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   Gene3D; 2.40.100.10; Cyclophilin-like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR029000; Cyclophilin-like_dom_sf.
DR   InterPro; IPR020892; Cyclophilin-type_PPIase_CS.
DR   InterPro; IPR002130; Cyclophilin-type_PPIase_dom.
DR   InterPro; IPR004130; Gpn.
DR   InterPro; IPR030231; Gpn2.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR21231:SF3; GPN-LOOP GTPASE 2; 1.
DR   PANTHER; PTHR21231; XPA-BINDING PROTEIN 1-RELATED; 1.
DR   Pfam; PF03029; ATP_bind_1; 2.
DR   Pfam; PF00160; Pro_isomerase; 1.
DR   PRINTS; PR00153; CSAPPISMRASE.
DR   SUPFAM; SSF50891; Cyclophilin-like; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF81631; PAP/OAS1 substrate-binding domain; 1.
DR   PROSITE; PS00170; CSA_PPIASE_1; 1.
DR   PROSITE; PS50072; CSA_PPIASE_2; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          540..657
FT                   /note="PPIase cyclophilin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50072"
FT   REGION          1031..1055
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1055 AA;  119458 MW;  9C0817E630296AB4 CRC64;
     MLLNSAVYRS LARRSILLTC SPTSVPYIID KFLKIGGSVN RAVYWPSQNG IQPVGTLLIQ
     SSSPESLRYT LHKIPSLHCI HCVVNSERKK SMFRLPMFRI NSDPSIWPVE NVEKYSSYQY
     PGRLCVESNL SIRPSVPSSK EMTSILMSCQ SFDDQVSTLY HLTRLTEQDI LARFVLSDSI
     EXXXXILGFI FRGTEVSIFG SVLNGLGSIS SDIDLVVKLP LNYDNLQYLC DSKPNCMTSD
     LFRTKIISLD PDFLKNKFLY FLQRMLRKLD XXXXYSQVYH GRVPIIHSDR ISILKVGLDI
     SSLTESTLVN NGESTHHGTK MAEILHFLTL CIPEIPKSVA LIKYLARKLR LTRNGPSPGF
     TNFKLISLFI NFLQVSNYAP SFIRLQSLIE NSIALDSASA FSVHLHFPDL NPFPSMEDLL
     GNFLVYVCSI KPCDIIIDLR NGCLTPRLES TDNEYTDHMI TPGKHFILCP DPTYPQCNIW
     SGINEDHWSK FVQICRVLQD TLEMQCNKNE NSKWGLLALT DLDDCTKSKF VNVSDYYQLN
     FLALCASDYY KGCIFHRNIK GFIVQTGDPT GTGKNGQSIW KKRFKDEFHD SLKHNARGIM
     SMANNGPDSN GSQFFITYSK QTMLDMKYSI FGKYYHTSSD QNQINIDYVM MSADSKPYPF
     PNGLHLFGQL VIGPPGSGKT TYCAAMHDFL VKLGRKVAVI NLDPANDSLP YPCAINMADL
     ICLDEVMDYL GLGPNGGLIY CMEYLYTNRS WLANQLAALK QKDPKIYLIF DLPGQVSQLC
     DVDHATKLFT CKRLCVELYT HHPCMRQLVC YLTNKPTNLK LNTKNQLSLP SSSIQSSSSN
     DEVPNSLDLQ LTSVHLIDSH YCSDAGKFIA CVLTSLSAML QLSIPHVNIF SKADLIEQYG
     ELDFNLDFFT EVLDLQYLID CLHKTTNNTD QLLFNCKYTR LNQAIIDLIQ DHSIVQFLLL
     DIQDLSHIER VMRYVDXXXX XXXXXXXXXX ANGYVFGTNE QHNLQSLLHS ASGVELAPDW
     IGMIQEKYTS KKNDDNHNID NNVQNDDEPH IDLFS
//