ID A0A183RP69_9TREM Unreviewed; 328 AA.
AC A0A183RP69;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=E1 ubiquitin-activating enzyme {ECO:0000256|ARBA:ARBA00012990};
DE EC=6.2.1.45 {ECO:0000256|ARBA:ARBA00012990};
OS Schistosoma rodhaini.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6188 {ECO:0000313|WBParaSite:SROB_0001782601-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:SROB_0001782601-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine
CC = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-
CC L-cysteine.; EC=6.2.1.45; Evidence={ECO:0000256|ARBA:ARBA00000488};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family.
CC {ECO:0000256|ARBA:ARBA00005673}.
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DR AlphaFoldDB; A0A183RP69; -.
DR STRING; 6188.A0A183RP69; -.
DR WBParaSite; SROB_0001782601-mRNA-1; SROB_0001782601-mRNA-1; SROB_0001782601.
DR GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR Gene3D; 1.10.10.2660; Ubiquitin-activating enzyme E1, SCCH domain; 2.
DR Gene3D; 3.10.290.60; Ubiquitin-activating enzyme E1, UFD domain; 1.
DR InterPro; IPR045886; ThiF/MoeB/HesA.
DR InterPro; IPR018965; Ub-activating_enz_E1_C.
DR InterPro; IPR038252; UBA_E1_C_sf.
DR InterPro; IPR019572; UBA_E1_SCCH.
DR InterPro; IPR042063; Ubi_acti_E1_SCCH.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR PANTHER; PTHR10953:SF4; UBA_E1_C DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR Pfam; PF09358; E1_UFD; 1.
DR Pfam; PF10585; UBA_E1_SCCH; 2.
DR SMART; SM00985; UBA_e1_C; 1.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE 3: Inferred from homology;
FT DOMAIN 227..320
FT /note="Ubiquitin-activating enzyme E1 C-terminal"
FT /evidence="ECO:0000259|SMART:SM00985"
SQ SEQUENCE 328 AA; 36807 MW; A931105542A80838 CRC64;
MGLNSCIGAG SGVKNWTDLR KDPPGFLERT LSNQGNQPLE TLETLKTNLL DKRPNSFEDC
VTWARLLWQP THLEFISAAS NLRAECYGIP QCRNLSKISE IVQSVIVPPF VPRSGVRIDV
TEAEAQARSA APMTDTSRLE KLQKALRSFT RSAAPMTDTS RLEKLQKALR SFSNTSRLHI
NVIEFEKDDD ANFHMDFITA ASNLRAENYE IPPADRLKSK LIAGKIIPAI ATTTSLVAGL
VCLELFKDSL KLNVTMLSQD VSMLYAFFMP EAKRKERLAM SLRDLVEVVN KRKIPPHVKV
LVFDVCCSDE HDKDVDVPYI RYVLEPAK
//
