ID   A0A183SDA7_SCHSO        Unreviewed;       678 AA.
AC   A0A183SDA7;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=tRNA (uracil-O(2)-)-methyltransferase {ECO:0000256|RuleBase:RU368004};
DE            EC=2.1.1.211 {ECO:0000256|RuleBase:RU368004};
GN   ORFNames=SSLN_LOCUS2205 {ECO:0000313|EMBL:VDL88590.1};
OS   Schistocephalus solidus (Tapeworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Diphyllobothriidea; Diphyllobothriidae; Schistocephalus.
OX   NCBI_TaxID=70667 {ECO:0000313|Proteomes:UP000050788, ECO:0000313|WBParaSite:SSLN_0000227501-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:SSLN_0000227501-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDL88590.1, ECO:0000313|Proteomes:UP000275846}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NST_G2 {ECO:0000313|EMBL:VDL88590.1,
RC   ECO:0000313|Proteomes:UP000275846};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-
CC       methyltransferase. {ECO:0000256|RuleBase:RU368004}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) = 2'-O-
CC         methyluridine(44) in tRNA(Ser) + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:43100, Rhea:RHEA-COMP:10339, Rhea:RHEA-COMP:10340,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:65315, ChEBI:CHEBI:74478; EC=2.1.1.211;
CC         Evidence={ECO:0000256|ARBA:ARBA00000660,
CC         ECO:0000256|RuleBase:RU368004};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|RuleBase:RU368004}.
CC   -!- SIMILARITY: Belongs to the TRM44 family.
CC       {ECO:0000256|ARBA:ARBA00009056, ECO:0000256|RuleBase:RU368004}.
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DR   EMBL; UYSU01032195; VDL88590.1; -; Genomic_DNA.
DR   STRING; 70667.A0A183SDA7; -.
DR   WBParaSite; SSLN_0000227501-mRNA-1; SSLN_0000227501-mRNA-1; SSLN_0000227501.
DR   Proteomes; UP000050788; Unplaced.
DR   Proteomes; UP000275846; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0141101; F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030488; P:tRNA methylation; IEA:UniProtKB-UniRule.
DR   InterPro; IPR011671; tRNA_uracil_MeTrfase.
DR   PANTHER; PTHR21210:SF0; TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED; 1.
DR   PANTHER; PTHR21210; UNCHARACTERIZED; 1.
DR   Pfam; PF07757; AdoMet_MTase; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU368004};
KW   Methyltransferase {ECO:0000256|RuleBase:RU368004};
KW   Reference proteome {ECO:0000313|Proteomes:UP000275846};
KW   S-adenosyl-L-methionine {ECO:0000256|RuleBase:RU368004};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU368004};
KW   tRNA processing {ECO:0000256|RuleBase:RU368004}.
FT   REGION          653..678
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   678 AA;  77396 MW;  66EFE67F67A2EA95 CRC64;
     MRYSSVFSIS MSSQISVYAY LCETYPRLAA AIAVWVEKPH VLNRKLFGAR LLMFSGDFAV
     RVVYPKLFTG LDPFTEEIRF ARILLRCYQY TLIAFLTVLL VGGSPKVTCM DVKNLQIFSP
     QWFIECLETR LCHWASLSLD HSPPSLKLVD YQNYQKVYLQ LKTYYLEYLR TVRLFVTLSN
     NFQSWCEKTD PEKFIHEDFG IAAYLICVWS NVKKEDVFFV DIGCGNGLLV YLLISEGVRF
     HGIGIDIKGR GIWKQYPARV AAALKSPSIN LQLFCANICF VKEETLDPST HPGFPKATLL
     IGNHSDELTP WLPILATKSN SECQVFTIPC CPFSLYQKFN DGHYNQQLKD GVYCQLTGGP
     QPSSAFTTEF PKEHSRLAEE GFWRGRYRRY IRYLENVLRI CGFEPELDIL RIPSTKRLCL
     LGRQHSKHLT YSKRLERVNK LIELESHAFL PRSCDDSSNS ATKFIPRPSD DGRQIPNLSI
     ADRDLICFRV FQRLLELKPN VQHLRDLGLT VSEDQRIQTP DQRWWNPGGQ LSLGAASAML
     TPDMRQGLKL VTGGLQTLLR NHHQAFIVTK NAIALRFDAY RLAHSAREGK RAQEPTARAI
     ELFKTKRCWM EANHPDGCPY PSEVCNFAHL SENLRPPPSD LEEVIDVIPR LRNNQEPGKD
     GMTADVYNSG VNNGVPAK
//