ID   A0A183T829_SCHSO        Unreviewed;       445 AA.
AC   A0A183T829;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=PKD_channel domain-containing protein {ECO:0000313|WBParaSite:SSLN_0001310701-mRNA-1};
GN   ORFNames=SSLN_LOCUS12627 {ECO:0000313|EMBL:VDL99012.1};
OS   Schistocephalus solidus (Tapeworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Diphyllobothriidea; Diphyllobothriidae; Schistocephalus.
OX   NCBI_TaxID=70667 {ECO:0000313|Proteomes:UP000050788, ECO:0000313|WBParaSite:SSLN_0001310701-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:SSLN_0001310701-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDL99012.1, ECO:0000313|Proteomes:UP000275846}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NST_G2 {ECO:0000313|EMBL:VDL99012.1,
RC   ECO:0000313|Proteomes:UP000275846};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC       {ECO:0000256|ARBA:ARBA00004272}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004272}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the polycystin family.
CC       {ECO:0000256|ARBA:ARBA00007200}.
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DR   EMBL; UYSU01037410; VDL99012.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A183T829; -.
DR   STRING; 70667.A0A183T829; -.
DR   WBParaSite; SSLN_0001310701-mRNA-1; SSLN_0001310701-mRNA-1; SSLN_0001310701.
DR   Proteomes; UP000050788; Unplaced.
DR   Proteomes; UP000275846; Unassembled WGS sequence.
DR   GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR   InterPro; IPR013122; PKD1_2_channel.
DR   InterPro; IPR003915; PKD_2.
DR   InterPro; IPR046791; Polycystin_dom.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10877:SF183; AT14535P-RELATED; 1.
DR   PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR   Pfam; PF08016; PKD_channel; 1.
DR   Pfam; PF20519; Polycystin_dom; 1.
DR   PRINTS; PR01433; POLYCYSTIN2.
PE   3: Inferred from homology;
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000275846};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        196..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        243..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        327..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        396..419
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          12..196
FT                   /note="Polycystin"
FT                   /evidence="ECO:0000259|Pfam:PF20519"
FT   DOMAIN          205..422
FT                   /note="Polycystin cation channel PKD1/PKD2"
FT                   /evidence="ECO:0000259|Pfam:PF08016"
FT   DISULFID        44..57
FT                   /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
SQ   SEQUENCE   445 AA;  50784 MW;  DC4793B503176F56 CRC64;
     MLAALYVNGQ ETRENGDTEF HIGTDNKLVG RPRIRQVAVR SVECALPNSL KKQVRLCYPN
     FDAKFESTAK LEPKFGQNLT YSTRAWTWSS VEEVGSGRID GDITSYPGSG YFIDLSTERN
     VTEAILEELF RGLWTTKATR AVIIDFTLYN ANLNLFCIGR QNLIMFFICA LIHRILFETP
     YTGGVISSAV FRPLRLLLGT GVTTKCVFTC EIITLAFVLY FVIEEILEIK HLGLAYFRKF
     WNLLDFTVVA FSLTCVILHC YGYIISFKLL GNGVTADAVY PEFVDIAYWC LQYNRMLALL
     VFFAMIKLFK FVSFSETMGQ LTATLSYAIY DLTGFTVMFG IVFSAFVQAG YLMFGRSSFE
     FCTFSQTAFV LYRIILGDFD MEAIKAAHST LGPLYFIIYI FFVFFVLLNM FLAIIGEAYS
     KVKDRMAKRT NDFKMMGYLR QARLF
//