ID A0A183WQ95_TRIRE Unreviewed; 508 AA.
AC A0A183WQ95;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Ig-like domain-containing protein {ECO:0000313|WBParaSite:TREG1_5350.1};
GN ORFNames=TRE_LOCUS14298 {ECO:0000313|EMBL:VDQ10178.1};
OS Trichobilharzia regenti (Nasal bird schistosome).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Trichobilharzia.
OX NCBI_TaxID=157069 {ECO:0000313|WBParaSite:TRE_0001491201-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TRE_0001491201-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDQ10178.1, ECO:0000313|Proteomes:UP000280995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000256|RuleBase:RU000687}.
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DR EMBL; UZAO01079420; VDQ10178.1; -; Genomic_DNA.
DR STRING; 157069.A0A183WQ95; -.
DR WBParaSite; TRE_0001491201-mRNA-1; TRE_0001491201-mRNA-1; TRE_0001491201.
DR WBParaSite; TREG1_5350.1; TREG1_5350.1; TREG1_5350.
DR Proteomes; UP000050795; Unassembled WGS sequence.
DR Proteomes; UP000280995; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd18987; LGIC_ECD_anion; 1.
DR CDD; cd19049; LGIC_TM_anion; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006028; GABAA/Glycine_rcpt.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR NCBIfam; TIGR00860; LIC; 1.
DR PANTHER; PTHR18945:SF937; NEUR_CHAN_LBD DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00253; GABAARECEPTR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU000687};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU000687};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW Reference proteome {ECO:0000313|Proteomes:UP000280995};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU000687};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000687};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU000687};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000687}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT CHAIN 24..508
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT /id="PRO_5041474316"
FT TRANSMEM 245..268
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 280..298
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 310..329
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 484..503
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT DOMAIN 32..244
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 252..498
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
SQ SEQUENCE 508 AA; 58143 MW; 8CCE10E30E77ECED CRC64;
MNIQLLIYRL ILITAYISYN GCAVVETSSI RDEIVETLFA NYQSHVRPGE LIQNTTVVTI
YISVSAITSV DVRNMEYTID MLLRQTWYDP RLAWDQIDKF KHYTKNIVSP VFKEKIWLPD
LFFRNGKEGR LHTMTCENLL IRIQPNGEIL YSQKITMRMA CQMELRTFPM DTQECYMDIG
SYGYTLEQIS FVWRNESPVD LNKDLQISEF DPPQAVRAYD CTSGYATSTG QYTCLNATFT
LQRQLGYWLA STYIPNILIM VVSWLNFWVS LEAIPARVNL SLLTLLGVIT QSTSYASSLP
RVSYIKAIDI WTIACITFNS GVLLEFAIAS HLARRQKVSE WQVEIRKLVR RELARWCSAC
QLQYAQRGPS ALSAYSSNRS NDKVSDYINS VAAVAFAIQN SPAIERTSPQ MSVRLTKSGL
LSTTAMKSGK TDKMSKNTFY ELVANDSALT SLDTTQKEAL LPPSEPQRVK KPASMSKIDS
YSRFLFPACF LLYNCFYWLY YLVVMKHK
//
