ID A0A183XEB1_WUCBA Unreviewed; 414 AA.
AC A0A183XEB1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195};
DE Short=MAD homolog {ECO:0000256|RuleBase:RU361195};
DE Short=Mothers against DPP homolog {ECO:0000256|RuleBase:RU361195};
DE AltName: Full=SMAD family member {ECO:0000256|RuleBase:RU361195};
GN ORFNames=WBA_LOCUS350 {ECO:0000313|EMBL:VDM06964.1};
OS Wuchereria bancrofti.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX NCBI_TaxID=6293 {ECO:0000313|WBParaSite:maker-PairedContig_1144-snap-gene-1.20-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:maker-PairedContig_1144-snap-gene-1.20-mRNA-1}
RP IDENTIFICATION.
RC STRAIN=pt0022
RC {ECO:0000313|WBParaSite:maker-PairedContig_1144-snap-gene-1.20-mRNA-1};
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDM06964.1, ECO:0000313|Proteomes:UP000270924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}.
CC Nucleus {ECO:0000256|RuleBase:RU361195}.
CC -!- SIMILARITY: Belongs to the dwarfin/SMAD family.
CC {ECO:0000256|ARBA:ARBA00005545, ECO:0000256|RuleBase:RU361195}.
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DR EMBL; UYWW01000043; VDM06964.1; -; Genomic_DNA.
DR STRING; 6293.A0A183XEB1; -.
DR WBParaSite; maker-PairedContig_1144-snap-gene-1.20-mRNA-1; maker-PairedContig_1144-snap-gene-1.20-mRNA-1; maker-PairedContig_1144-snap-gene-1.20.
DR OMA; QPMDTGN; -.
DR Proteomes; UP000270924; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009791; P:post-embryonic development; IEA:UniProt.
DR GO; GO:0050793; P:regulation of developmental process; IEA:UniProt.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0051239; P:regulation of multicellular organismal process; IEA:UniProt.
DR Gene3D; 2.60.200.10; -; 1.
DR Gene3D; 3.90.520.10; SMAD MH1 domain; 1.
DR InterPro; IPR013790; Dwarfin.
DR InterPro; IPR003619; MAD_homology1_Dwarfin-type.
DR InterPro; IPR013019; MAD_homology_MH1.
DR InterPro; IPR017855; SMAD-like_dom_sf.
DR InterPro; IPR001132; SMAD_dom_Dwarfin-type.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR036578; SMAD_MH1_sf.
DR PANTHER; PTHR13703:SF67; DWARFIN SMA-2-RELATED; 1.
DR PANTHER; PTHR13703; SMAD; 1.
DR Pfam; PF03165; MH1; 1.
DR Pfam; PF03166; MH2; 1.
DR SMART; SM00523; DWA; 1.
DR SMART; SM00524; DWB; 1.
DR SUPFAM; SSF56366; SMAD MH1 domain; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS51075; MH1; 1.
DR PROSITE; PS51076; MH2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU361195};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361195};
KW Reference proteome {ECO:0000313|Proteomes:UP000270924};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU361195};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU361195}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 12..138
FT /note="MH1"
FT /evidence="ECO:0000259|PROSITE:PS51075"
FT DOMAIN 217..414
FT /note="MH2"
FT /evidence="ECO:0000259|PROSITE:PS51076"
SQ SEQUENCE 414 AA; 47144 MW; E90A83FD9F049DDF CRC64;
MKFENLLGQR GTAVAKCLGW KQGDEEESWS KKAIDSLMKK LQKHNKEALA SLEMALQCQG
RQRTDCVTIP RSLDGRLQIS HRKALPHVIY CRVYRWPDLQ SHHELKAIDD CRYCYESGQK
DVCINPYHYE RVESAGILPP VLVPRYTEPP PHIIPRLLHI SRLQTTPSAS SMPCNIDFSH
YSDAVMMSKR DDEMDASVII PNGVTTIEIP YEEGKFWATI SYFELNTRVG EQYKVSSPTV
EIDGFTDPTS NPGKICLGLL SNVNRNQQIE STRRRIGRGV KLTYVPNQGT LFAECQSESA
IFIQSRNCNY FHSFHPTTVC KITNGISLKI FDMSKFRELL AESTRCCSFD AIYELTNMTI
IRMSFVKGWG AEYQRQDVTS TPCWVEIHLH APLQWLDKVL SQMGPPPNPI SSIS
//
