ID   A0A191THU9_9BACT        Unreviewed;       458 AA.
AC   A0A191THU9;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=Hemolysin {ECO:0008006|Google:ProtNLM};
GN   ORFNames=A9P82_02550 {ECO:0000313|EMBL:ANI88281.1};
OS   Arachidicoccus sp. BS20.
OC   Bacteria; Bacteroidota; Chitinophagia; Chitinophagales; Chitinophagaceae;
OC   Arachidicoccus.
OX   NCBI_TaxID=1850526 {ECO:0000313|EMBL:ANI88281.1, ECO:0000313|Proteomes:UP000078308};
RN   [1] {ECO:0000313|EMBL:ANI88281.1, ECO:0000313|Proteomes:UP000078308}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BS20 {ECO:0000313|EMBL:ANI88281.1,
RC   ECO:0000313|Proteomes:UP000078308};
RA   Im W.T., Siddiqi M.Z.;
RT   "Arachidicoccus sp. BS20 whole genome sequincing.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; CP015971; ANI88281.1; -; Genomic_DNA.
DR   RefSeq; WP_066203907.1; NZ_CP015971.1.
DR   AlphaFoldDB; A0A191THU9; -.
DR   KEGG; arb:A9P82_02550; -.
DR   OrthoDB; 9798188at2; -.
DR   Proteomes; UP000078308; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.30.465.10; -; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR002550; CNNM.
DR   InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR   InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   InterPro; IPR005170; Transptr-assoc_dom.
DR   PANTHER; PTHR43099:SF5; INTEGRAL MEMBRANE PROTEIN-RELATED; 1.
DR   PANTHER; PTHR43099; UPF0053 PROTEIN YRKA; 1.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF01595; CNNM; 1.
DR   Pfam; PF03471; CorC_HlyC; 1.
DR   SMART; SM00116; CBS; 2.
DR   SMART; SM01091; CorC_HlyC; 1.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   PROSITE; PS51846; CNNM; 1.
PE   4: Predicted;
KW   CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW   ProRule:PRU00703}; Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000078308};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU01193};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW   ProRule:PRU01193}.
FT   TRANSMEM        21..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        151..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          13..217
FT                   /note="CNNM transmembrane"
FT                   /evidence="ECO:0000259|PROSITE:PS51846"
FT   DOMAIN          236..295
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   DOMAIN          300..357
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
SQ   SEQUENCE   458 AA;  51469 MW;  D3E0224A938E425D CRC64;
     MSSDIPPAEQ MIEHSVNLYK VLLTIFLVLL NGFFVAAEFA IVKVRTSQLS TAKGASARLL
     NTAKTVTNNL DNYLAATQLG VTLASLGLGW VGEDVMTGIV QKLFHFFNIS LSTPAANKWA
     IVLAFFIITV LHIVFGELAP KSIAIRKASP TTLAVALPLR AFFFVFRPFI WLLNSMANIV
     LKILGIDPVK EQDIHTEEEI KMIISESEEG GEIEDSEREL INNVFDFDSS RVRDILTHRK
     DIVALDIDMS YEEIIQKVID EGYSRYPVYK ESLNDLIGIV TVKDILQFVS SGKTEDIHKI
     LRPVFYIPDS MKLKDLLRSF QKDHLQIAVV TDEYGDIAGI VTMEDVLEEL VGDIQDEHDA
     EQPIVLQQSD GSFIVESHET IDDINEFLPK PLPILDEEYS TLSGLITYEH GSVPVEGEVL
     HYCGYEITIL KMYRSSVEKV RMRLLPEEEK AADDNTNK
//