ID A0A191URI9_HUMAN Unreviewed; 304 AA.
AC A0A191URI9; A0A1W2PQZ7;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Killer cell immunoglobulin-like receptor 2DS1 {ECO:0000313|Ensembl:ENSP00000492002.2};
DE SubName: Full=Killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 1 {ECO:0000313|EMBL:ANJ04807.1};
GN Name=KIR2DS1 {ECO:0000313|EMBL:ANJ04807.1,
GN ECO:0000313|Ensembl:ENSP00000492002.2};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ANJ04807.1};
RN [1] {ECO:0000313|Ensembl:ENSP00000492002.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2] {ECO:0000313|EMBL:ANJ04807.1}
RP NUCLEOTIDE SEQUENCE.
RA Roe D., Vierra-Green C., Pyo C.-W., Eng K., Hall R., Spellman S.,
RA Ranade S., Geraghty D.E., Maiers M.;
RT "Full Haplotype Sequences of the Killer Immunoglobulin-like Receptor (KIR)
RT Region in Several Diverse Diploid Individuals using Single Molecule, Real-
RT Time Sequencing.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSP00000492002.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC {ECO:0000256|ARBA:ARBA00008637}.
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DR EMBL; KU645197; ANJ04807.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A191URI9; -.
DR SMR; A0A191URI9; -.
DR BioMuta; ENSG00000283937; -.
DR MassIVE; A0A191URI9; -.
DR Ensembl; ENST00000639697.1; ENSP00000492100.1; ENSG00000283937.3.
DR Ensembl; ENST00000640974.2; ENSP00000492002.2; ENSG00000283937.3.
DR HGNC; HGNC:6333; KIR2DS1.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; A0A191URI9; Protein.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR11738:SF168; KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR 2DL2-RELATED; 1.
DR PANTHER; PTHR11738; MHC CLASS I NK CELL RECEPTOR; 1.
DR Pfam; PF00047; ig; 2.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
PE 3: Inferred from homology;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:ANJ04807.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..304
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015052679"
FT TRANSMEM 244..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 34..114
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
FT DOMAIN 134..221
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
FT REGION 220..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..304
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 304 AA; 33632 MW; FD322511B4940CC2 CRC64;
MSLTVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGRLVK SEETVILQCW SDVMFEHFLL
HREGMFNDTL RLIGEHHDGV SKANFSISRM KQDLAGTYRC YGSVTHSPYQ LSAPSDPLDI
VIIGLYEKPS LSAQPGPTVL AGENVTLSCS SRSSYDMYHL SREGEAHERR LPAGTKVNGT
FQANFPLGPA THGGTYRCFG SFRDSPYEWS KSSDPLLVSV TGNPSNSWPS PTEPSSETGN
PRHLHILIGT SVVKIPFTIL LFFLLHRWCS DKKNAAVMDQ EPAGNRTVNS EDSDEQDHQE
VSYA
//
