ID A0A191UVH7_9ACTN Unreviewed; 300 AA.
AC A0A191UVH7;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=S1 family peptidase {ECO:0000313|EMBL:RDD88659.1};
DE SubName: Full=Serine protease {ECO:0000313|EMBL:GGR86941.1};
DE SubName: Full=Streptogrisin {ECO:0000313|EMBL:ANJ06736.1};
GN ORFNames=DVZ84_11765 {ECO:0000313|EMBL:RDD88659.1}, GCM10010220_44240
GN {ECO:0000313|EMBL:GGR86941.1}, Spa2297_06855
GN {ECO:0000313|EMBL:ANJ06736.1};
OS Streptomyces parvulus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=146923 {ECO:0000313|EMBL:ANJ06736.1, ECO:0000313|Proteomes:UP000078468};
RN [1] {ECO:0000313|EMBL:ANJ06736.1, ECO:0000313|Proteomes:UP000078468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2297 {ECO:0000313|EMBL:ANJ06736.1,
RC ECO:0000313|Proteomes:UP000078468};
RA Nishizawa T., Miura T., Harada C., Guo Y., Narisawa K., Ohta H.,
RA Takahashi H., Shirai M.;
RT "Non-Contiguous Finished Genome Sequence of Streptomyces parvulus 2297
RT Integrated Site-Specifically with Actinophage R4.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:RDD88659.1, ECO:0000313|Proteomes:UP000253742}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2297 {ECO:0000313|EMBL:RDD88659.1,
RC ECO:0000313|Proteomes:UP000253742};
RA Hu D.;
RT "Genome guided investigation of antibiotics producing actinomycetales
RT strain isolated from a Macau mangrove ecosystem.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:GGR86941.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCM 4068 {ECO:0000313|EMBL:GGR86941.1};
RX PubMed=30832757;
RA Wu L., Ma J.;
RT "The Global Catalogue of Microorganisms (GCM) 10K type strain sequencing
RT project: providing services to taxonomists for standard genome sequencing
RT and annotation.";
RL Int. J. Syst. Evol. Microbiol. 69:895-898(2019).
RN [4] {ECO:0000313|EMBL:GGR86941.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCM 4068 {ECO:0000313|EMBL:GGR86941.1};
RA Sun Q., Ohkuma M.;
RL Submitted (DEC-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S1 family.
CC {ECO:0000256|ARBA:ARBA00007664}.
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DR EMBL; CP015866; ANJ06736.1; -; Genomic_DNA.
DR EMBL; BMRX01000010; GGR86941.1; -; Genomic_DNA.
DR EMBL; QQBH01000006; RDD88659.1; -; Genomic_DNA.
DR RefSeq; WP_064727121.1; NZ_QQBH01000006.1.
DR STRING; 146923.Spa2297_06855; -.
DR KEGG; spav:Spa2297_06855; -.
DR OrthoDB; 8781117at2; -.
DR Proteomes; UP000078468; Chromosome.
DR Proteomes; UP000253742; Unassembled WGS sequence.
DR Proteomes; UP000645274; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd21112; alphaLP-like; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR004236; Pept_S1_alpha_lytic.
DR InterPro; IPR001316; Pept_S1A_streptogrisin.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR006311; TAT_signal.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR Pfam; PF02983; Pro_Al_protease; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PIRSF; PIRSF001134; Streptogrisin; 1.
DR PRINTS; PR00861; ALYTICPTASE.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51318; TAT; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001134-2};
KW Hydrolase {ECO:0000313|EMBL:GGR86941.1};
KW Protease {ECO:0000313|EMBL:GGR86941.1}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..38
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 39..300
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041083672"
FT DOMAIN 45..99
FT /note="Peptidase S1A alpha-lytic prodomain"
FT /evidence="ECO:0000259|Pfam:PF02983"
FT DOMAIN 116..292
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|Pfam:PF00089"
FT ACT_SITE 149
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR001134-1"
FT ACT_SITE 178
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR001134-1"
FT ACT_SITE 255
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR001134-1"
FT DISULFID 129..150
FT /evidence="ECO:0000256|PIRSR:PIRSR001134-2"
FT DISULFID 249..277
FT /evidence="ECO:0000256|PIRSR:PIRSR001134-2"
SQ SEQUENCE 300 AA; 29863 MW; C108332C95B857F3 CRC64;
MRIKRTTPRS GITRRTRLIA VSTGLVAAAA VAIPSATAAP APVAFSAAEL SSASGAVLKA
DVPGTAWAVD AKSGRVLLTV DSTVSQAEIA KIKEQAGDKA GALTVKRTPG TFNKLIQGGD
AIYASSWRCS LGFNVRASNG TEYFLTAGHC TDGAGAWRSS SGGTVIGQTA GSSFPGNDYG
IVQYTGSVSR PGTANGVDIT RAATPSVGTT VIRDGSTTGT HSGRVTALNA TVNYGGGDVV
GGLIQTTVCA EPGDSGGSLY GSNGTAYGLT SGGSGNCSSG GTTFFQPVTE ALSAYGVSVY
//
