ID A0A191V405_9ACTN Unreviewed; 238 AA.
AC A0A191V405;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Urease subunit gamma/beta {ECO:0000256|HAMAP-Rule:MF_01955};
DE EC=3.5.1.5 {ECO:0000256|HAMAP-Rule:MF_01955};
DE AltName: Full=Urea amidohydrolase subunit gamma/beta {ECO:0000256|HAMAP-Rule:MF_01955};
GN Name=ureAB {ECO:0000256|HAMAP-Rule:MF_01955,
GN ECO:0000313|EMBL:GGR90394.1};
GN ORFNames=GCM10010220_48470 {ECO:0000313|EMBL:GGR90394.1},
GN Spa2297_23385 {ECO:0000313|EMBL:ANJ09660.1};
OS Streptomyces parvulus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=146923 {ECO:0000313|EMBL:ANJ09660.1, ECO:0000313|Proteomes:UP000078468};
RN [1] {ECO:0000313|EMBL:ANJ09660.1, ECO:0000313|Proteomes:UP000078468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2297 {ECO:0000313|EMBL:ANJ09660.1,
RC ECO:0000313|Proteomes:UP000078468};
RA Nishizawa T., Miura T., Harada C., Guo Y., Narisawa K., Ohta H.,
RA Takahashi H., Shirai M.;
RT "Non-Contiguous Finished Genome Sequence of Streptomyces parvulus 2297
RT Integrated Site-Specifically with Actinophage R4.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:GGR90394.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCM 4068 {ECO:0000313|EMBL:GGR90394.1};
RX PubMed=30832757;
RA Wu L., Ma J.;
RT "The Global Catalogue of Microorganisms (GCM) 10K type strain sequencing
RT project: providing services to taxonomists for standard genome sequencing
RT and annotation.";
RL Int. J. Syst. Evol. Microbiol. 69:895-898(2019).
RN [3] {ECO:0000313|EMBL:GGR90394.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCM 4068 {ECO:0000313|EMBL:GGR90394.1};
RA Sun Q., Ohkuma M.;
RL Submitted (DEC-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+); Xref=Rhea:RHEA:20557,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16199,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:28938; EC=3.5.1.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000242, ECO:0000256|HAMAP-
CC Rule:MF_01955};
CC -!- PATHWAY: Nitrogen metabolism; urea degradation; CO(2) and NH(3) from
CC urea (urease route): step 1/1. {ECO:0000256|ARBA:ARBA00004897,
CC ECO:0000256|HAMAP-Rule:MF_01955}.
CC -!- SUBUNIT: Heterohexamer of 3 UreC (alpha) and 3 UreAB (gamma/beta)
CC subunits. {ECO:0000256|HAMAP-Rule:MF_01955}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01955}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the urease beta
CC subunit family. {ECO:0000256|HAMAP-Rule:MF_01955}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the urease gamma
CC subunit family. {ECO:0000256|HAMAP-Rule:MF_01955}.
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DR EMBL; CP015866; ANJ09660.1; -; Genomic_DNA.
DR EMBL; BMRX01000012; GGR90394.1; -; Genomic_DNA.
DR RefSeq; WP_064729986.1; NZ_JAMOLM010000010.1.
DR AlphaFoldDB; A0A191V405; -.
DR KEGG; spav:Spa2297_23385; -.
DR UniPathway; UPA00258; UER00370.
DR Proteomes; UP000078468; Chromosome.
DR Proteomes; UP000645274; Unassembled WGS sequence.
DR GO; GO:0035550; C:urease complex; IEA:InterPro.
DR GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR GO; GO:0009039; F:urease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0043419; P:urea catabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00407; Urease_beta; 1.
DR CDD; cd00390; Urease_gamma; 1.
DR Gene3D; 2.10.150.10; Urease, beta subunit; 1.
DR Gene3D; 3.30.280.10; Urease, gamma-like subunit; 1.
DR HAMAP; MF_01955; Urease_beta_gamma; 1.
DR InterPro; IPR002019; Urease_beta-like.
DR InterPro; IPR036461; Urease_betasu_sf.
DR InterPro; IPR008223; Urease_gamma-beta_su.
DR InterPro; IPR002026; Urease_gamma/gamma-beta_su.
DR InterPro; IPR036463; Urease_gamma_sf.
DR NCBIfam; TIGR00192; urease_beta; 1.
DR NCBIfam; TIGR00193; urease_gam; 1.
DR PANTHER; PTHR33569; UREASE; 1.
DR PANTHER; PTHR33569:SF1; UREASE; 1.
DR Pfam; PF00699; Urease_beta; 1.
DR Pfam; PF00547; Urease_gamma; 1.
DR PIRSF; PIRSF001225; Urease_gammabeta; 1.
DR SUPFAM; SSF51278; Urease, beta-subunit; 1.
DR SUPFAM; SSF54111; Urease, gamma-subunit; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01955};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_01955}.
FT REGION 1..101
FT /note="Urease gamma"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01955"
FT REGION 102..238
FT /note="Urease beta"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01955"
SQ SEQUENCE 238 AA; 24543 MW; 571D045FA551FCF3 CRC64;
MRLTPTERDR LLLFGAAQLA RARRDRGLRL NVPEATALIA DTVCEAARDG ARLAEALERA
RSVLGPDDVL PGVADVVTEV HVEAVFDDGS RLAVVSDPIG GGGLGPAGPG ALLPGPDHAE
PEAALRLPVT NTATVPVSVT SHFHFFEANP RLDFDRERAY GMRLAVPAGS SVRFGPGESA
EVGLVPIGGR RIAIGFAGLV DGPLDAPGAK EEALRRAAAC GYLGVPPVAD GSPEGGAR
//
