ID A0A191V7S8_9ACTN Unreviewed; 790 AA.
AC A0A191V7S8;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Family 65 glycosyl hydrolase {ECO:0000313|EMBL:GGR67515.1};
DE SubName: Full=Trehalose 6-phosphate phosphorylase {ECO:0000313|EMBL:ANJ10948.1};
GN ORFNames=GCM10010220_19250 {ECO:0000313|EMBL:GGR67515.1},
GN Spa2297_30575 {ECO:0000313|EMBL:ANJ10948.1};
OS Streptomyces parvulus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=146923 {ECO:0000313|EMBL:ANJ10948.1, ECO:0000313|Proteomes:UP000078468};
RN [1] {ECO:0000313|EMBL:ANJ10948.1, ECO:0000313|Proteomes:UP000078468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2297 {ECO:0000313|EMBL:ANJ10948.1,
RC ECO:0000313|Proteomes:UP000078468};
RA Nishizawa T., Miura T., Harada C., Guo Y., Narisawa K., Ohta H.,
RA Takahashi H., Shirai M.;
RT "Non-Contiguous Finished Genome Sequence of Streptomyces parvulus 2297
RT Integrated Site-Specifically with Actinophage R4.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:GGR67515.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCM 4068 {ECO:0000313|EMBL:GGR67515.1};
RX PubMed=30832757;
RA Wu L., Ma J.;
RT "The Global Catalogue of Microorganisms (GCM) 10K type strain sequencing
RT project: providing services to taxonomists for standard genome sequencing
RT and annotation.";
RL Int. J. Syst. Evol. Microbiol. 69:895-898(2019).
RN [3] {ECO:0000313|EMBL:GGR67515.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCM 4068 {ECO:0000313|EMBL:GGR67515.1};
RA Sun Q., Ohkuma M.;
RL Submitted (DEC-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 65 family.
CC {ECO:0000256|ARBA:ARBA00006768}.
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DR EMBL; CP015866; ANJ10948.1; -; Genomic_DNA.
DR EMBL; BMRX01000004; GGR67515.1; -; Genomic_DNA.
DR RefSeq; WP_064731277.1; NZ_CP015866.1.
DR AlphaFoldDB; A0A191V7S8; -.
DR KEGG; spav:Spa2297_30575; -.
DR Proteomes; UP000078468; Chromosome.
DR Proteomes; UP000645274; Unassembled WGS sequence.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 2.70.98.40; Glycoside hydrolase, family 65, N-terminal domain; 1.
DR Gene3D; 2.60.420.10; Maltose phosphorylase, domain 3; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR005194; Glyco_hydro_65_C.
DR InterPro; IPR005195; Glyco_hydro_65_M.
DR InterPro; IPR005196; Glyco_hydro_65_N.
DR InterPro; IPR037018; Glyco_hydro_65_N_sf.
DR InterPro; IPR017045; Malt_Pase/Glycosyl_Hdrlase.
DR PANTHER; PTHR11051; GLYCOSYL HYDROLASE-RELATED; 1.
DR PANTHER; PTHR11051:SF8; PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE; 1.
DR Pfam; PF03633; Glyco_hydro_65C; 1.
DR Pfam; PF03632; Glyco_hydro_65m; 1.
DR Pfam; PF03636; Glyco_hydro_65N; 1.
DR PIRSF; PIRSF036289; Glycosyl_hydrolase_malt_phosph; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000313|EMBL:GGR67515.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 10..257
FT /note="Glycoside hydrolase family 65 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03636"
FT DOMAIN 309..704
FT /note="Glycoside hydrolase family 65 central catalytic"
FT /evidence="ECO:0000259|Pfam:PF03632"
FT DOMAIN 714..778
FT /note="Glycoside hydrolase family 65 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03633"
FT ACT_SITE 485
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR036289-50"
FT BINDING 346..347
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR036289-51"
FT BINDING 605..606
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR036289-51"
SQ SEQUENCE 790 AA; 88553 MW; D27155D8C66FFCF1 CRC64;
MTATPSTWDY DHYDAAEERL RESLCTLGNG YFATRGALPE CAADDLHYPG TYAAGCYNRL
TSTVAGREVE NEDMVNLPNW LPLRFRPVGE EWLTPDTAQV LDHRQTVHLD SGVLERRTRF
GLGGGRVLSV RQLRLVHMAY PHLAALRTEF TTESGPVDLE VESALDGGVT NSGVPRYRQL
EGRHLVHVHT GGADGAVWLR CRTRTSDIRV GMAARTTAEE PVTPAREHLC VTQRTTLRPE
PGRTVTVDKI VALHTSRDPA ISDPLQAAID RVAAAPGFDE LLVSHRTAWG QLWRRAELDV
PGEAGSILRL HLFHVLQTLS PHTAELDVGV PARGLHGEAY RGHVFWDELF VLPYLNLHFP
EVSRALLHYR HRRLERARAA ARAIGRRGAL YPWQSGSDGR EETQQLHLNP RSGRWLPDHS
HLQHHVGSAI AYNVWQYCEA SGDAEFLHTK GAETLLQIAR FWADSADWDD RLGRHRIRGV
VGPDEYHEAY PGARRPGLDD NAYTNVTASW VLTRALEVLA DLPEPRRREL VERTSLDDGE
LEQWDSVSRT LHVPFHEGVV SQFEGYGDLA ELDWAGYRER YGDIRRLDRV LEAENDSVNN
YQASKQADVL MLGYLFSPTE LLALFGRLGY RLDEETWQRT VDYYLARTSH GSTLSGLVHG
WILARARRAE AWAFCQEALK GDVADLQGGT TGEGIHLGAM AGTLDLVQRG LTGLETRAGA
LWLDPVPLPE LSSYGFSVRY QGHWGVRFRL EHGRLEIAVP ESGPLPIDVR LPDREVRLQP
GDTCRLVLPD
//
