ID A0A193GFV0_9BORD Unreviewed; 635 AA.
AC A0A193GFV0;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=DNA (cytosine-5-)-methyltransferase {ECO:0000256|ARBA:ARBA00011975};
DE EC=2.1.1.37 {ECO:0000256|ARBA:ARBA00011975};
GN ORFNames=BAU07_19040 {ECO:0000313|EMBL:ANN78937.1};
OS Bordetella flabilis.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Alcaligenaceae; Bordetella.
OX NCBI_TaxID=463014 {ECO:0000313|EMBL:ANN78937.1, ECO:0000313|Proteomes:UP000091926};
RN [1] {ECO:0000313|EMBL:ANN78937.1, ECO:0000313|Proteomes:UP000091926}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AU10664 {ECO:0000313|EMBL:ANN78937.1,
RC ECO:0000313|Proteomes:UP000091926};
RA LiPuma J.J., Spilker T.;
RT "Complete genome sequences of Bordetella bronchialis and Bordetella
RT flabilis.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-
CC methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:11370,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:85452, ChEBI:CHEBI:85454; EC=2.1.1.37;
CC Evidence={ECO:0000256|ARBA:ARBA00000743};
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016}.
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DR EMBL; CP016172; ANN78937.1; -; Genomic_DNA.
DR RefSeq; WP_066660933.1; NZ_CP016172.1.
DR AlphaFoldDB; A0A193GFV0; -.
DR STRING; 463014.BAU07_19040; -.
DR REBASE; 154093; M2.Bfl10664ORF19035P.
DR KEGG; bfz:BAU07_19040; -.
DR OrthoDB; 9813719at2; -.
DR Proteomes; UP000091926; Chromosome.
DR GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR10629; CYTOSINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10629:SF50; DNA (CYTOSINE-5)-METHYLTRANSFERASE CMT3; 1.
DR Pfam; PF00145; DNA_methylase; 2.
DR PRINTS; PR00105; C5METTRFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}.
FT ACT_SITE 88
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 635 AA; 68519 MW; BA3EEA776718A8CD CRC64;
MIRNQFVLDV HPEILVDNFA GGGGASTGIE MALGRCVDIA INHDPEAVAM HEINHPQTRH
YCESVWDVDP VEATQGRPVG LAWFSPDCKH FSKAKGGKPR DKRIRGLAWI VLRWAALVRP
RVIMLENVEE FRTWGPLLES GQPCPARKGQ TFRSFIHQLQ EKGYAVEHRE LRACDYGAPT
IRKRLFLIAR CDGQPIVWPE PTHGAPTSPE VQAGQRKPWR TAADCIDWSI PCPSIFERQR
PLAEATLRRI ARGIRRYVID AAQPFIVGAG GPVYSGKPVP ANRPFGALTT ENHRHVVVPH
ITKFRTGSTG AALGEPMPTI TAGPKENPAG APHAVGIVAP SLVKVNHGGD DFRGRPLDAP
IATLTGKHGT GIVAPTLVQA GFGERPGQAP RCLDLHKPLG TVTAQGRKHA LVSAFLAKHY
GGNYDGPGLP LGGPMHTATT VDHHAVVAAQ LVGCGGRAGQ SRPRDAGEPA QTLTAKADTC
VVTSHLAKLR NNQFGQATDE PMPTLTAGGG HVADVRAFLV KYYSEGGQDQ DCRDPMHTIP
TKDRIGLVTV AGQEYVIADI GMRMLEPHEL YAAQGFPGDY IIAPTINGRR LPKHAQVRMC
GNSVCPPLAA ALVRANVSDL SAWTPREAKE KRVAA
//
