ID   A0A193H210_9CAUD        Unreviewed;       279 AA.
AC   A0A193H210;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   13-SEP-2023, entry version 21.
DE   RecName: Full=thymidylate synthase {ECO:0000256|ARBA:ARBA00011947};
DE            EC=2.1.1.45 {ECO:0000256|ARBA:ARBA00011947};
OS   Shigella phage SHSML-45.
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Demerecviridae; Markadamsvirinae; Tequintavirus; Tequintavirus SHSML45.
OX   NCBI_TaxID=1863010 {ECO:0000313|EMBL:ANN87165.1, ECO:0000313|Proteomes:UP000201391};
RN   [1] {ECO:0000313|EMBL:ANN87165.1, ECO:0000313|Proteomes:UP000201391}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Das C.R., Woolston J., Li M., Sulakvelidze A., Soffer N.;
RT   "Genetic Characterization of ShigActive phages.";
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the thymidylate synthase family.
CC       {ECO:0000256|ARBA:ARBA00009972}.
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DR   EMBL; KX130863; ANN87165.1; -; Genomic_DNA.
DR   RefSeq; YP_009280286.1; NC_031022.1.
DR   GeneID; 29062808; -.
DR   KEGG; vg:29062808; -.
DR   Proteomes; UP000201391; Genome.
DR   GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR   Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR   HAMAP; MF_00008; Thymidy_synth_bact; 1.
DR   InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR   InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR   InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR   InterPro; IPR000398; Thymidylate_synthase.
DR   NCBIfam; TIGR03284; thym_sym; 1.
DR   PANTHER; PTHR11548:SF9; THYMIDYLATE SYNTHASE; 1.
DR   PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR   Pfam; PF00303; Thymidylat_synt; 1.
DR   PRINTS; PR00108; THYMDSNTHASE.
DR   SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:ANN87165.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000201391};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ANN87165.1}.
FT   DOMAIN          2..278
FT                   /note="Thymidylate synthase/dCMP hydroxymethylase"
FT                   /evidence="ECO:0000259|Pfam:PF00303"
SQ   SEQUENCE   279 AA;  31905 MW;  DEDAC358C2998818 CRC64;
     MQQYLKILTD VILLGEPRND RTGTGTVSIF DSYAKFDLRE GFPAVTTKRL AWKSVVGELL
     WFLSGSTNLH DLRVFTFGRD EGQWTIWTPN YEDQAISMGY DNGNLGPVYG KQWRNFGGRD
     QILELIEGLK NNPHGRRHLV SAWNVAELDK MALPPCHYGF QCYVSNDGYL DLKWTQRSVD
     CFLGLPFNIA SYALLTHILA KLTGLKPRYL IFSGGDTHIY NDHIEQVEEQ MKRKPRPLPT
     LVMPEFVDLY DLLDNNTAAW SFHLEGYDPH PALKAKMSS
//