ID A0A193LIM1_9GAMM Unreviewed; 163 AA.
AC A0A193LIM1;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase {ECO:0000256|ARBA:ARBA00016218};
DE EC=2.7.6.3 {ECO:0000256|ARBA:ARBA00013253};
DE AltName: Full=6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase {ECO:0000256|ARBA:ARBA00029766};
DE AltName: Full=7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase {ECO:0000256|ARBA:ARBA00033413};
GN ORFNames=BA177_14520 {ECO:0000313|EMBL:ANO52244.1};
OS Woeseia oceani.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales; Woeseiaceae;
OC Woeseia.
OX NCBI_TaxID=1548547 {ECO:0000313|EMBL:ANO52244.1, ECO:0000313|Proteomes:UP000092695};
RN [1] {ECO:0000313|EMBL:ANO52244.1, ECO:0000313|Proteomes:UP000092695}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XK5 {ECO:0000313|EMBL:ANO52244.1,
RC ECO:0000313|Proteomes:UP000092695};
RA Mu D., Du Z.;
RT "Complete genome sequence of a deep-branching marine Gamma Proteobacterium
RT Woeseia oceani type strain XK5.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the transfer of pyrophosphate from adenosine
CC triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic
CC step in folate biosynthesis pathway. {ECO:0000256|ARBA:ARBA00029409}.
CC -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-
CC 4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-
CC dihydroneopterin triphosphate: step 4/4.
CC {ECO:0000256|ARBA:ARBA00005051}.
CC -!- SIMILARITY: Belongs to the HPPK family.
CC {ECO:0000256|ARBA:ARBA00005810}.
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DR EMBL; CP016268; ANO52244.1; -; Genomic_DNA.
DR RefSeq; WP_068617376.1; NZ_CP016268.1.
DR AlphaFoldDB; A0A193LIM1; -.
DR STRING; 1548547.BA177_14520; -.
DR KEGG; woc:BA177_14520; -.
DR UniPathway; UPA00077; UER00155.
DR Proteomes; UP000092695; Chromosome.
DR GO; GO:0003848; F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046656; P:folic acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00483; HPPK; 1.
DR Gene3D; 3.30.70.560; 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; 1.
DR InterPro; IPR000550; Hppk.
DR InterPro; IPR035907; Hppk_sf.
DR NCBIfam; TIGR01498; folK; 1.
DR PANTHER; PTHR43071; 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE; 1.
DR PANTHER; PTHR43071:SF2; 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE; 1.
DR Pfam; PF01288; HPPK; 1.
DR SUPFAM; SSF55083; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Folate biosynthesis {ECO:0000256|ARBA:ARBA00022909};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ANO52244.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000092695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 5..128
FT /note="7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase"
FT /evidence="ECO:0000259|Pfam:PF01288"
SQ SEQUENCE 163 AA; 18438 MW; 3A6E430F02AE35B0 CRC64;
MTRVYVGIGS NLRPEQNLQL AIRELAARYH QLDVSPVYRN PAVGFDGDDF LNMVAAFDCE
QTPEQLLESF EQIHDLASRV RGGDRLVSRT LDIDLLLYGD RIQDKPPLPR EDVLDYLFVL
KPLAELAPNL RHPLTGMTMA EHLAAKQCAE HRLDRVELGF ALS
//
