ID   A0A194PCM7_PAPXU        Unreviewed;       378 AA.
AC   A0A194PCM7;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Sodium channel protein Nach {ECO:0008006|Google:ProtNLM};
GN   ORFNames=RR46_14550 {ECO:0000313|EMBL:KPI91046.1};
OS   Papilio xuthus (Asian swallowtail butterfly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC   Papilionidae; Papilioninae; Papilio.
OX   NCBI_TaxID=66420 {ECO:0000313|EMBL:KPI91046.1, ECO:0000313|Proteomes:UP000053268};
RN   [1] {ECO:0000313|EMBL:KPI91046.1, ECO:0000313|Proteomes:UP000053268}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPI91046.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:KPI91046.1};
RX   PubMed=26354079; DOI=10.1038/ncomms9212;
RA   Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA   Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA   Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA   Wang W.;
RT   "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL   Nat. Commun. 6:8212-8212(2015).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|ARBA:ARBA00007193,
CC       ECO:0000256|RuleBase:RU000679}.
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DR   EMBL; KQ459606; KPI91046.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A194PCM7; -.
DR   STRING; 66420.A0A194PCM7; -.
DR   Proteomes; UP000053268; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.287.820; Acid-sensing ion channel domain; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR001873; ENaC.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   PANTHER; PTHR11690:SF248; DEGENERIN-LIKE PROTEIN UNC-105; 1.
DR   Pfam; PF00858; ASC; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053268};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT   TRANSMEM        338..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   378 AA;  42781 MW;  4997DE65847067CB CRC64;
     MPRVCVHLSS DTFTFYTPLG TAADVPEKLL PNNVSSFAQN ALTVSNVYPR NYTEEYLRAH
     IQQLAAFFSP DVFYRLDDLE IIENVLDYNK VDVETAGLSL TASCEESISR DLTELESVPA
     PPNYRINKNL DFTGGLMLVV NQSLATPFDV DISYKWLSLH GNQRFINLPG NGTPITPGTE
     LHAGFIPNML RVDEDAANLD RDQKRCRMSY EALEYFPVYH KQHCLMEIEM RRTIELCGCL
     KLGHLHVPGV PVCRARSLQC ARLASVSFGK FNSNCPVTCD ADAMDYFTTS SYDLNGNISP
     NDDFYADLDF TKVSILRIYV RHRHKVLLRK SYFTNFELFA QLGGLFSVFF GCSVLSIWEL
     VMLLWRAAST KIASINRK
//