ID A0A194PDA5_PAPXU Unreviewed; 1138 AA.
AC A0A194PDA5;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=60S ribosomal export protein NMD3 {ECO:0000256|ARBA:ARBA00017035};
GN ORFNames=RR46_14820 {ECO:0000313|EMBL:KPI91316.1};
OS Papilio xuthus (Asian swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=66420 {ECO:0000313|EMBL:KPI91316.1, ECO:0000313|Proteomes:UP000053268};
RN [1] {ECO:0000313|EMBL:KPI91316.1, ECO:0000313|Proteomes:UP000053268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPI91316.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPI91316.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- FUNCTION: Acts as an adapter for the XPO1/CRM1-mediated export of the
CC 60S ribosomal subunit. {ECO:0000256|ARBA:ARBA00002269}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a sphingomyelin + H2O = an N-acylsphing-4-enine + H(+) +
CC phosphocholine; Xref=Rhea:RHEA:19253, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17636, ChEBI:CHEBI:52639,
CC ChEBI:CHEBI:295975; EC=3.1.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00023999};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19254;
CC Evidence={ECO:0000256|ARBA:ARBA00023999};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the NMD3 family.
CC {ECO:0000256|ARBA:ARBA00009794}.
CC -!- SIMILARITY: Belongs to the acid sphingomyelinase family.
CC {ECO:0000256|ARBA:ARBA00008234}.
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DR EMBL; KQ459606; KPI91316.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A194PDA5; -.
DR STRING; 66420.A0A194PDA5; -.
DR Proteomes; UP000053268; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.
DR GO; GO:0043023; F:ribosomal large subunit binding; IEA:InterPro.
DR GO; GO:0004767; F:sphingomyelin phosphodiesterase activity; IEA:UniProtKB-EC.
DR GO; GO:0046513; P:ceramide biosynthetic process; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd00842; MPP_ASMase; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR045473; ASM_C.
DR InterPro; IPR041805; ASMase/PPN1_MPP.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR039768; Nmd3.
DR InterPro; IPR007064; Nmd3_N.
DR InterPro; IPR048898; NMD3_OB.
DR InterPro; IPR048899; NMD_SH3.
DR InterPro; IPR011001; Saposin-like.
DR InterPro; IPR008139; SaposinB_dom.
DR PANTHER; PTHR12746:SF2; 60S RIBOSOMAL EXPORT PROTEIN NMD3; 1.
DR PANTHER; PTHR12746; NONSENSE-MEDIATED MRNA DECAY PROTEIN 3; 1.
DR Pfam; PF19272; ASMase_C; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF04981; NMD3; 1.
DR Pfam; PF21192; NMD3_OB; 1.
DR Pfam; PF21193; NMD_SH3; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR SUPFAM; SSF47862; Saposin; 1.
DR PROSITE; PS50015; SAP_B; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000053268};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 555..645
FT /note="Saposin B-type"
FT /evidence="ECO:0000259|PROSITE:PS50015"
SQ SEQUENCE 1138 AA; 130284 MW; 4F54BF7F6F2CB809 CRC64;
MEYISPEDVP APNSTRILCC QCATPIEPNP SNMCVACLRA HVDITDGIPK QATLFFCRGC
ERYLQPPAEW LVCALESREL LALCLKRLKG LNRVKLIDAG FAWTEPHSKR IKVKLTVQGE
VMGGAVLQQT FIVEFVIQHQ MCDACHRSEA QDYWRALVQV RQRANNRKTF YYLEQLILKH
KAHENTLGIK PKHDGLDFFY ATENTARKMV DFVQSVLPIK CQHSKKLISH DIHSNIYNYK
FTYSIEIVPV SKDSVVCLPK KLTHQLGSIS PICLVSRVTS TIHLIDPNTG QVCDLSSTVY
WRHPFTPICN PKQLVEYTVM DIDILKEHEK KTFPGQGVVS NKHVIADVWV VKSSELGHDV
NPIHTKTHLG HILKPGDTVL GYNLCDTNVN DANFDKLDKD SIPDVFLVKK YYGEKSARRR
ARNWKLKHMA DDLHEGLGSS NEDYNEFLDD LEEDPAFRQN INIFKDENRV PIDTDEIDPS
LPRITLAEML DDLNIEDVDM TESVFTEDEV ETVIGKYMKN ELLSSDEQKL QEDVFEILRR
TQHVTTHEYR SDVRMSLDCL VCRSAFSALF ELIRAGASDD DLTRSLSNIC VLLGIESYNV
CSGAISLNLN IITYIIRNTP EATPRNFCGL VLQRSDNPNF CSYNDSRFEW HVELPQRIQA
ANVLTPVIDQ SPLTVAILTD AHIDPLYEAF GVAQCDEPTC CRKGQRLRPS SDIVTDGSEV
ENSVIGHGEN ILLNLGDVPK IKEIRMRNSM RAQTRYVEPA GYWGDYRNCD TPRWAYDDLI
ERMASSHKFD VVYYIGDTID HGIWETSYEL IDEINQYLIN KMRTSFGEDV LIIPAIGNHE
SQPTNQFAPV SVTGAKLNTT WLYEGLVNKW DHYLTEEAKA SLRVHGGFSR LVRPGLRAIS
LNTNIAYKYN WWLVYDPLEM KRHLEWLVQE LRGAELAGEK VHILSHIPPG VHDLAHIWTR
EYNKIVNRFS STIAAEFNGH IHSDEFKIFY STVEPKLPIN VAWGVGAATA YTNYNLNYKI
ATFNPAPQSI NNYIYNLTEA NLTPNRRPHW FQLYDMKNSF GVKDLSAQSM DDLLQRMVTT
DRNLLDLYAA YVPKLSDRRW PYCNNNCKLD HLCRIVTTVL WQREKCDELR LLFSNTNT
//
