ID A0A194PDQ5_PAPXU Unreviewed; 1980 AA.
AC A0A194PDQ5;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 22-FEB-2023, entry version 20.
DE RecName: Full=Nipped-B protein {ECO:0000256|RuleBase:RU364107};
GN ORFNames=RR46_14985 {ECO:0000313|EMBL:KPI91481.1};
OS Papilio xuthus (Asian swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=66420 {ECO:0000313|EMBL:KPI91481.1, ECO:0000313|Proteomes:UP000053268};
RN [1] {ECO:0000313|EMBL:KPI91481.1, ECO:0000313|Proteomes:UP000053268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPI91481.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPI91481.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364107}.
CC -!- SIMILARITY: Belongs to the SCC2/Nipped-B family.
CC {ECO:0000256|ARBA:ARBA00009252, ECO:0000256|RuleBase:RU364107}.
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DR EMBL; KQ459606; KPI91481.1; -; Genomic_DNA.
DR STRING; 66420.A0A194PDQ5; -.
DR Proteomes; UP000053268; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0061780; P:mitotic cohesin loading; IEA:InterPro.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR026003; Cohesin_HEAT.
DR InterPro; IPR024986; Nipped-B_C.
DR InterPro; IPR033031; Scc2/Nipped-B.
DR PANTHER; PTHR21704:SF18; NIPPED-B-LIKE PROTEIN; 1.
DR PANTHER; PTHR21704; NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED; 1.
DR Pfam; PF12765; Cohesin_HEAT; 1.
DR Pfam; PF12830; Nipped-B_C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU364107};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364107};
KW Reference proteome {ECO:0000313|Proteomes:UP000053268};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364107}.
FT DOMAIN 1605..1790
FT /note="Sister chromatid cohesion C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12830"
FT REGION 141..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 623..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 913..933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 976..1021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1937..1980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1980 AA; 223524 MW; 9AC9C70FE0AB3903 CRC64;
MNERDIPSVP ITTLAGVASL TDLLPVLPLP TPLPSTLNNK SQLFHPRVAE EAAILLATRD
DNLVSLLLQS LMQTSVQHID LKDESIPNAV SPSPQQDTPE LLKAILNVNP NIFDQRNEQR
NHWSNHLHSS KFNGMSPSST FNYSSHSAAH SSPSSHGTAV HSGPIPNQQL LATPCQSSPH
VHMGSPPSQA RPGQQVNITA QNNISPSWTS TNQSNIYTSP ISNTPCTNPQ NGGFYNSLVQ
DNRFGTNLNE DKDPLSMSPG NLQDQQRVML QTQEKPFEQD GNVMTGQSPA QASVAPSPLR
HEPQAPQPSM GAPYAPQQST TQDKLELSTK TPNIMNNKYP VVKIGRLSEG ILKKHDFAND
GRSRKSSAIE SDSDDNLPLK AKSTVSNPTV DKEREAIDLA RERNWEAVKR KHEEASKKEE
AEAAIVRPKL RKVEKRLVPV LEMLSVDELM ETNTYQRFSK LIDAVFETID DDVIITDEME
GPEIPEELLL PRYQLQELCS EAAKLKNLGA MEAIPSDRLV RLLSILEKNI RAAEKMSLLG
DPEDSEEMRQ IWIESALERV MCASDACLTA LYIMTSPSMP KRIFLEDVID RIILFIKFQL
NNTIYCVYDP VYSIQSTYKK KVDGRKRRGG GAGNATRRSG GGSGSNRAVR ELYSHAHECV
TLLAELFAAH HLTDTTVLHA STVGVSPFFV ENISELQLSA LKLVTTIFSK YEQHRRLLLE
DILASIARIP SSKHNLRSFQ LSSDQHIQML TALVLQLVQC VVTLPETMCK TQDKDKEKDK
EHSEADNKKQ VDKDLIIISK YEAAISVGGT FLTSFLNKCR SRSEEVDFRP LFENFVHDLL
TTVNKPEWPA TELLLSLLGT MLVKYMSDKS MEMSVRVASL EYLGLVAARL RRDSVHSRAK
LSTMDAVVRD IRAEEEKDAG HTQTTTSGLD EDEERTEFLQ RVLLDYLAIN GQKDQAWNCA
RHFYITQWYR DMVIQPKASP TKRPKNKSKK RYKDETSDEE SEPDDDSDSE LKESKVDKRH
SSSAVMSAEK FKTIERRKHF FLEKIRPFRY QGGTQVQVMQ SYIDYSGAEL ISQYLASKRS
FSQSFDRYLR KILVILCENT IAIRTKAMKC LTMIVEADPS VLARPDMQIG VNRSFLDQST
AVREAAVDLV GKFVLSRPDL IDKYYGMLSN RILDTGVSVR KRVIKILKDI CIECPEFPKI
PEICVKMIRR VNDEEGIRKL VMEVFQNMWF SPCPNTSRPG ALDTTAAAAD PLTRKVLNIT
DVVISSRDMG LEWFQQLLTS LFKPKEDKED STKIIYQPPK SLLVACQQIV DCLIENLLQL
EETDGTGSSQ RILACLSTLH LFAKIRPQLL VNHALTLQPY LSLKCQNQYE QQIMSTVAST
LELVVPLMEH PSEVFLAQLE EDAVKLILQR GQLVIAACIA CLAAIVNNLT HNYKLIRDVF
NKYHGVLLQW KSSWQRNPEL TRSLPSRPYF RRALFIVGLL LRYFDFTDNR VIEGLSSDIK
EQVFGTLMFF VALDDEDFVS HTLKALGSVC VRHYELMLRA DLKEFYHQLL TSDLAPIEMK
ADVLKNIEMY LQEEEQRMIR QDKEWSKRSK HENLKEMGDV SSGMASTVIQ LYLKEILGSF
LHPSTVVRSS AMKVVQLVLA QGLVHPVQIV PYLICMSTDV EVTVSHTADK NLQDIDKKYP
GFIHMKAQLG IKLSYQLQKI LQNKTDKGII RGFRKKDQDD LPTSLNGFLY SLLRNTRPQR
RALVLSLLKQ FDDVSTAPLD QMLYLADNLS YFPYQVQDEP LFIIHHIDII ISTSGSNLLQ
LFREGLIKPN AEQEKESLDE EEDEEEAEAL LLRLPHNTRP LRDAMRQARG CVLLLVLKQH
LKQQYGFTDA KINQYSPSES VKMYEKAVSR RHAPLFEPKV TIAHLRAAAR EHVEDELDED
GRRRLVDDYL EFKQLMLKFD PEEEEEEEAG SGATPQGAAG GAGEAGARPA PAAPPPPPAT
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