ID A0A194PHE3_PAPXU Unreviewed; 972 AA.
AC A0A194PHE3;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Signal-induced proliferation-associated 1-like protein 2 {ECO:0000313|EMBL:KPI92831.1};
GN ORFNames=RR46_14052 {ECO:0000313|EMBL:KPI92831.1};
OS Papilio xuthus (Asian swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=66420 {ECO:0000313|EMBL:KPI92831.1, ECO:0000313|Proteomes:UP000053268};
RN [1] {ECO:0000313|EMBL:KPI92831.1, ECO:0000313|Proteomes:UP000053268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPI92831.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPI92831.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
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DR EMBL; KQ459603; KPI92831.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A194PHE3; -.
DR STRING; 66420.A0A194PHE3; -.
DR Proteomes; UP000053268; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF70; RAP-GAP DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000053268}.
FT DOMAIN 401..618
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT DOMAIN 762..826
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 826..884
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 830..852
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 972 AA; 107038 MW; D5BCDEF73F606732 CRC64;
MYAPDHLRRK EVRDVMYRSN SSLDLIYTEH PSGNSLRREY GSHGSIDVIG GTSDRLPAMV
HNYSGVSTPD KQPGLGRADR LAEVLASDHA DGPPPRSSVS PKPRLKLNKL WGGAAPVLSR
QPLDDGALPS TVPEEVKRKQ FAHYDCQSLM ANLSYAAEIR GALLSRRRNT TTGASAASLL
ATRGLPPGED AVPDTGDGRS NELLESCPFF RNELGGEEER CISLCSRTAR GAIPGQYGGW
HRPRAAYGFS VLEFPPGHTH WRQGCPFARS LAPLPVESQD LGALYYRNYF YTQPHQNWFG
MEENIGPVAI SIKKERVELR RGGGDALAPA SQLAWHYRVI VRTAELLTIR GSVLEDALPT
VKPSNNSATY NTKDVLEYIA PEIQLSCLRL GITNSGAEEQ LLRLDEQCVT RHYKVGVMYC
KSGQSTEEEM YNNQEAGPAF VEFLQMLGQT VRLKDFDKYK AGLDNRTDST GLYSVYTTYQ
GCEIMFHVST MLPYTPNNRQ QLLRKRHIGN DIVTIVFQEP GAAPFTPRNI RSQFQHVFVV
VRVIDPCTEN THYSIAVSRA KEVPLFGPPI KDGAVYPKGD AFTDLLLSKV INGENAAIQS
PKFNTMATRT RQEYLKDLAK NYVTATTVET GQKFSIFSSL LMKSGNNSNS STVIPRLDNC
TNDVLVRGAL CFHVQVQDEG AGGNLLDCIM GVSADSIVLI EDSSRQIVLV LPTNTLLGWV
VSGGWSRVYY HRGESVRMRG APEALLRRLA SVAPPHAHNL HEITLERGQA AQLGFHVQPD
GLVTAVEGGG CAARAGVRRG ARLLEVCRAA VVALHHDQLV DLLKTSDPVT VGGSGRSMRQ
QRSPQTSPVS ESARRAEPRH SRRPRSSPAA PAPATPGTAP ASQNNSLTEE LMRLMDAELG
EGHNEGAGRG PPLPLPDAAA LDWATLVHTA TRAMLQVRRL RRHNARLREE SARAVWQLRH
FTQWLKRTVD RQ
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