ID A0A194PII9_PAPXU Unreviewed; 1242 AA.
AC A0A194PII9;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=pyruvate carboxylase {ECO:0000256|ARBA:ARBA00013057};
DE EC=6.4.1.1 {ECO:0000256|ARBA:ARBA00013057};
GN ORFNames=RR46_14409 {ECO:0000313|EMBL:KPI90905.1};
OS Papilio xuthus (Asian swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=66420 {ECO:0000313|EMBL:KPI90905.1, ECO:0000313|Proteomes:UP000053268};
RN [1] {ECO:0000313|EMBL:KPI90905.1, ECO:0000313|Proteomes:UP000053268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPI90905.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPI90905.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
CC -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC {ECO:0000256|ARBA:ARBA00004742}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KQ459606; KPI90905.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A194PII9; -.
DR STRING; 66420.A0A194PII9; -.
DR UniPathway; UPA00138; -.
DR Proteomes; UP000053268; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004736; F:pyruvate carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR GO; GO:0006090; P:pyruvate metabolic process; IEA:InterPro.
DR CDD; cd06850; biotinyl_domain; 1.
DR CDD; cd07937; DRE_TIM_PC_TC_5S; 1.
DR Gene3D; 1.10.10.2790; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 2.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR Gene3D; 1.10.472.90; Conserved carboxylase domain; 1.
DR Gene3D; 3.10.600.10; pyruvate carboxylase f1077a mutant domain; 2.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR003379; Carboxylase_cons_dom.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR000891; PYR_CT.
DR InterPro; IPR005930; Pyruv_COase.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR NCBIfam; TIGR01235; pyruv_carbox; 1.
DR PANTHER; PTHR43778; PYRUVATE CARBOXYLASE; 1.
DR PANTHER; PTHR43778:SF2; PYRUVATE CARBOXYLASE, MITOCHONDRIAL; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR Pfam; PF00682; HMGL-like; 1.
DR Pfam; PF02436; PYC_OADA; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF51569; Aldolase; 2.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF89000; post-HMGL domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
DR PROSITE; PS50991; PYR_CT; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Gluconeogenesis {ECO:0000256|ARBA:ARBA00022432};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409};
KW Pyruvate {ECO:0000256|ARBA:ARBA00023317, ECO:0000313|EMBL:KPI90905.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053268}.
FT DOMAIN 38..488
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 160..355
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 583..896
FT /note="Pyruvate carboxyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50991"
FT DOMAIN 1167..1242
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
SQ SEQUENCE 1242 AA; 137073 MW; 2388208DD8269E08 CRC64;
MQILNARYAL RASATQLQAW SSVRHRTATT DTTVEYKPIR SVLVANRGEI AIRVFRACTE
LGIRSVAIYS EQDRLQMHRQ KADESYLVGK GLPPVEAYLN IPEIIRVAKE NDVDAVHPGY
GLLSERSDFA HAIIDAGLRF IGPSPKVVQQ MGDKVAARKA AIEAKVPIVP GTDGPVTTKE
EAVEFCKQHG LPVIFKAAYG GGGRGMRVVR EMSEVASAFE RASSEALGAF GNGSMFIERF
IERPRHIEVQ LLGDKAGNVV HLYERDCSVQ RRHQKVVEIA PAPRLDPQVR QQMVDCAVHL
ARHVGYENAG TVEFLLDDKG NFYFIEVNAR LQVEHTITEE VTGIDLVQSQ IKVAEGLTLP
ELGLTQDKIK TQGYAIQCRV TTEDPANNFQ PSTGRIEVFR SGEGMGIRLD SASTYAGAII
SPYYDSLLVK VISHAQDLSA SAAKMNRALR EFRIRGVKTN IPFLLNVLEN QKFLNGAVDT
YFIDEHPQLF MFKVSQNRAQ KILNYLGYVL VNGPATPLAT NIPPSDVKPY IPPIPLDLSP
EAIKRQEMTG ENTAVQPPKG FKQILNEGGP EAFARAVREH KGLLLMDTTF RDAHQSLLAT
RVRTHDLLAV SPYVAHNFSN LYALENWGGA TFDVALRFLH ECPWERLEDM RRLIPNIPFQ
MLLRGANAVG YTNYPDNAVY KFLHECPWER LEDMRRLIPN IPFQMLLRGA NAVGYTNYPD
NAVYKFCDMA VKSGMDIFRV FDSLNYLPNL ILGMDAAGKA GGVVEAAISY TGDVSDPNKK
KYDLKYYLNL ADELVKAGTH VLAIKDMAGL LKPRAAELLI TAIRDKHPSI PIHVHTHDTS
GAGVAAMLAC ARAGADAVDV AVDAMSGLTS QPSMGAMVAS LQGDKLDTGI PLQNVSEYSA
YWEQARTLYG PFECTATMKS GNADVYINEI PGGQYTNLQF QAFSLGLGSQ FEQVKKAYRE
ANLLLGDIIK VTPSSKVVGD LAQFMVQNKL SAKDIEEKAE ELSFPKSVVE YLQGAIGIPY
GGFPEPLRSK VLKDMPRIEG RPGQELPPLD FDKLKAELLE SFPDVTDKDV MSAAMYPQVA
NDFFRIRDKY GPVKHLDTKT FLVGPTVGET IEVKIERGKT LDIKTLAVSE EMTSAGEREV
FFELNGQLRS VFIRDENASK EMKIHPKAVK GDKDQVGAPM PGTVLTIKVK EGDKVEKGQP
IAVLSAMKME MIVQAPRAGT IKTVSITNGQ KLEGDDLICT IE
//