ID A0A194PKG4_PAPXU Unreviewed; 1277 AA.
AC A0A194PKG4;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN ORFNames=RR46_15089 {ECO:0000313|EMBL:KPI91585.1};
OS Papilio xuthus (Asian swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=66420 {ECO:0000313|EMBL:KPI91585.1, ECO:0000313|Proteomes:UP000053268};
RN [1] {ECO:0000313|EMBL:KPI91585.1, ECO:0000313|Proteomes:UP000053268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPI91585.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPI91585.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC -!- SIMILARITY: Belongs to the SARM1 family.
CC {ECO:0000256|ARBA:ARBA00008291}.
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DR EMBL; KQ459606; KPI91585.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A194PKG4; -.
DR STRING; 66420.A0A194PKG4; -.
DR Proteomes; UP000053268; Unassembled WGS sequence.
DR GO; GO:0050135; F:NAD(P)+ nucleosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0061809; F:NAD+ nucleotidase, cyclic ADP-ribose generating; IEA:UniProtKB-EC.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0019677; P:NAD catabolic process; IEA:UniProt.
DR GO; GO:0034128; P:negative regulation of MyD88-independent toll-like receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048678; P:response to axon injury; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09501; SAM_SARM1-like_repeat1; 1.
DR CDD; cd09502; SAM_SARM1-like_repeat2; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR039184; SARM1.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR22998:SF1; NAD(+) HYDROLASE SARM1; 1.
DR PANTHER; PTHR22998; SARM1; 1.
DR Pfam; PF07647; SAM_2; 2.
DR Pfam; PF13676; TIR_2; 1.
DR SMART; SM00454; SAM; 2.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunity {ECO:0000256|ARBA:ARBA00022588};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000053268};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 941..1005
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 1088..1231
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 66..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 342..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 466..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1240..1277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..499
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1277 AA; 140860 MW; 5178EDBCF01A8931 CRC64;
MSRYDKRLGL NRSETVFVSR TRDQGIRNTT LGIPEFKLDG NNSLKHNGSA KDLASVMENL
KKSSLVSRQN QTLNTQVTSS SSQQMVSSTT SSSAASSQRL QSSSQRLQHM TASEMKASSM
KSDLTELKSS ISEMKNLSSC SALNFGQRLR SSMENIVDQD DGHLADIRDL DEIGDYSDMG
DIGDMGGDAP LVTFPESDTP PPVSDKACML AGNNVPVAVG GGGSGAPNEL KYATSRVTSA
SSTRVVADGY SASRSAANSA RLRRLQHGDL QYAERSAAGA SHRLLQAEGL TAEQNDAYLQ
ALIYSGMSLT YPPYIRREKL SVSTCSTPDL YEVYKGAPKD ATSRVQDDRY YTTPGRPTQG
DGSETLSTLA STLSLIATDS WSEQHGSFLE HGAHHSMDRE SAQARRISAS AAEREHTRVA
RGSGIAVLRT RSDTRIADFK FRSGMSGGGS VPWPVHRRVL SRYPAVPLGP SEQRSLKAGE
VSAQEANNMS ASSSRLQTEA FSAEKKAMAS AQARQTVTSS GMFSHKEHSS VAHSNMTISS
KNLSTKSTLL SSQMSQLLNG SIKPGDEDLT NLTFEDLDKL NANSNQKDVD LAIQKYSSRM
NAFINSIKNN QIDIKNASVH FNKLNEMMRR AWAVPTYGHE LGYSLCNTLR TSGGLDILME
NCVETNNPEL QFSSAKLLEQ CLTTENRAHV VENGLEKVVN VACICTQYAN SVEHSRVRTG
ILEHLFKHSE GTCSDVIKLG GLDAVLFECR KNDIETLRHC ATALANLSLY GGAENQEAMI
KRKVPMWLFP LAFHTDDNVK YYACLAIAVL VANKEIEAAV LKSGTLNLVE PFVTSHNPSE
FAKSNLSHAH GQSKNWLQKL VPVLSSKREE ARNLAAFHFC MEAGIKKQQG NTEIFREIGA
IESLKKVASC PNAVASKYAA QALRLIGEEV PHKLSQQVPL WSIEDVKEWV KQIGFSEYAN
NFQESRVDGD LLLQISEDNL KEDIGLLNGI KRKRFTRELQ QLKKMADYSS RDTGSLNEFL
QSIGPEYTIY TYSMLNAGVD KESMRGLSDE QLENECHIVN SIHRLRILNA IRVYESTLPS
KGEENMEKNL DVFVSYRRSN GSQLASLLKV HLQLRGFTVF IDVERLEAGK FDNNLLQSIS
HAKNFLLVLT PNALERCKHD TEQKDWVHRE IVAALQSQCN IVPIIDNFEW PEPEELPEDM
RAVCHFNGVR WIHDYQDACV EKLESFLRGK SNLATRLEGG LRGRGDVATP GTASIGRGPP
SYQRMASCES RASDKTD
//