ID A0A194PL06_PAPXU Unreviewed; 1340 AA.
AC A0A194PL06;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Protein toll {ECO:0000313|EMBL:KPI94116.1};
GN ORFNames=RR46_06567 {ECO:0000313|EMBL:KPI94116.1};
OS Papilio xuthus (Asian swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=66420 {ECO:0000313|EMBL:KPI94116.1, ECO:0000313|Proteomes:UP000053268};
RN [1] {ECO:0000313|EMBL:KPI94116.1, ECO:0000313|Proteomes:UP000053268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPI94116.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPI94116.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; KQ459600; KPI94116.1; -; Genomic_DNA.
DR RefSeq; XP_013173364.1; XM_013317910.1.
DR STRING; 66420.A0A194PL06; -.
DR GeneID; 106122060; -.
DR KEGG; pxu:106122060; -.
DR OrthoDB; 927694at2759; -.
DR Proteomes; UP000053268; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 6.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR026906; LRR_5.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24369; ANTIGEN BSP, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR24369:SF210; CHAOPTIN-RELATED; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13306; LRR_5; 1.
DR Pfam; PF13855; LRR_8; 6.
DR Pfam; PF13676; TIR_2; 1.
DR SMART; SM00365; LRR_SD22; 13.
DR SMART; SM00369; LRR_TYP; 22.
DR SMART; SM00082; LRRCT; 2.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 8.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053268};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1340
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008263363"
FT TRANSMEM 1014..1038
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1068..1207
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1271..1303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1271..1288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1289..1303
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1340 AA; 151963 MW; D5222DB574F99C82 CRC64;
MQATVLLLWY SVWCGLRSGA GGAALTSRVA EAPQECEWQR VSGGPGEPTR VQLACSLRTA
AGATDLLAGL SASQAQRITA LDLHCTDVLF FESSLDVGRR KEEGTELLSR FHNLKELRIE
SCKIRYVPSA VLSPLSGLRT LSIRTHNTDW SAMSMEFHRD TFRGLTDLRI LDLGDNNIWV
LPSEIFCPLY NLKELNVTQN RLQDISNLGF SDWGNGPTAP GKSCNTVLET LDMSQNEISG
LPDNGLSSLR ALQKLFLQDN RISTVADRAF VGLSDLQILN LSTNALTALP PEMFQSSRDI
KQIYLNNNSL SVLAPGLLEG LDQLQILDLS VNELTSEWVN RDTFSGLVRL IVLNLSHNKI
SKIDALLFQD LNNLQFLSLE FNNIARIADG AFSNLKNLHS LSLAHNNIIE VDSGHFSNLY
VLNQLFLDGN RITKIDLRSF ENITKLHDLG LSGNQLTEVP EAIKTLRFLT SLDLGMNRIT
KVTTSQFEGL DDLYGLRLVG NKIEKISKDT FVALPSLQIL NLASNNIDQI DDGAFSSNQQ
LKAIGLDGNK LVDLKGIFTN SQPLVWLNVS NNELLWFDYS YIPTNVEWLD MHENKIEKLE
DTYGLKESCN IKMLDVSHNK IRSLDEFSFP SSVETIVLNN NHIEDINPGT FLQKYNLNKV
ILYSNKIKTL EVGAFAISAV SEDKDLPEFY ISENPFDCDC TMEWLQRINQ LSDLRQRPRV
MDLESVRCSL THSRNKLGVF LLEVKSSEFL CKYDSHCFTL CHCCDFDACD CKMTCPDNCT
CYHDLTWNSN VVYCSNAGYD HVPDRMPMDA TEIYLDGNDL KELGNHVFIG KKRLQVLYLN
NSNINTIQNR TFNGIESLRV LHLENNKLEV LRNTQFTRLP NLNELYLNEN KIKVIENDTF
NYLPSLEYLN LENNGYVDYM PWRVITDNNP RTRVSVDGNN WICDCKDVAQ LNQWLIKKSK
DTETMMCYFA HGQSMNKTIA TVAKECKTET TTEETGTETL KRLFIETNDG VENYIPYIAV
VLIIVIILLV MCAFLFMFRE DFKLWMHSKY GVRVFSSSSK DMNDNKNKRF DAFFVYNPRD
EDFVTRAVSS ELENSGHSLC LQHRDLQLIE RRSGDSLSSA SESSKRLVIV LSINFLEQEW
YSPESKAAIQ SAINSVNVRH RRQKIIFLVT TDLSAINIDP DLKVLLKTCT VIVWGEKNCW
EKLNFRLPDV DVTLPNRTLH NANNMKTSNR EAFGRHGNLR YTAPPTSQDP WYKYGMAPPI
LMMSSPMHST SASAEVSARS TEDETCSVAS SEGRPDDRLP HHHSYVSIDN HQCEERPLRP
AQQIPMSNTR PANVRKTYFV
//
