ID A0A194PM34_PAPXU Unreviewed; 625 AA.
AC A0A194PM34;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Inhibitor of nuclear factor kappa-B kinase subunit epsilon {ECO:0000313|EMBL:KPI94496.1};
GN ORFNames=RR46_05748 {ECO:0000313|EMBL:KPI94496.1};
OS Papilio xuthus (Asian swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=66420 {ECO:0000313|EMBL:KPI94496.1, ECO:0000313|Proteomes:UP000053268};
RN [1] {ECO:0000313|EMBL:KPI94496.1, ECO:0000313|Proteomes:UP000053268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPI94496.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPI94496.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
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DR EMBL; KQ459598; KPI94496.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A194PM34; -.
DR STRING; 66420.A0A194PM34; -.
DR Proteomes; UP000053268; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR Gene3D; 1.20.1270.420; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR041087; TBK1_ULD.
DR PANTHER; PTHR22969:SF15; FI05319P; 1.
DR PANTHER; PTHR22969; IKB KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF18396; TBK1_ULD; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KPI94496.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000053268};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 12..310
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 468..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..492
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 41
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 625 AA; 68415 MW; 9195644392C331A3 CRC64;
MSFLRGSENY VWCTTSVLGK GATGAVFQGV NKNNGEPVAV KTFNQLSHMR PHDVQMREFE
VLKKVKHENI VKLLAIEEEQ EGRGKVIVME LCTGGSLFNI LDDPENTYGL QEHEFLLVLE
HLTAGMKHLR DNNLVHRDLK PGNIMKFINE DGTTTYKLTD FGAARELQEE EQFISLYGTE
EYLHPDMYER AVLRKPVGKS FGATVDLWSI GVTLYHVATG QLPFRPYGGR RNKETMFFIT
TKKASGVISG TQTTDNGPID WSRELPSHCQ LSVGLRKLVT PLLAGLLEVF LKPEEKYEHL
QTYVCEQTSV VPEAQILLFQ ERLLLAEVAA ATPGRKYPDT TAEEPLLLFN KNNNNVSMAP
EPDVPKFPVF PNIVSVENDA SQAKTACSVG HVVRRRVEAL CASAVLCARC VSRWGALLDS
RLQRVDARAE ALGARAHCLA QAARALALAA PALCSPVAAT GALDRAPSAG AAAARRAPRQ
RARRRHRRLV SPAPLPRPRP RPPPRAAGYK VAQTVFLQTQ ILDKDVSGAE LRLAALSARL
QDAEQQAQAQ AALGSAHLAS SKTETVDKEK EKEKVKEECQ KREGVSAGGA GVRALLAAQD
DLAAGLASNR ALVARLVHAA HALRP
//
