ID A0A194PQ52_PAPXU Unreviewed; 509 AA.
AC A0A194PQ52;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Deoxyribodipyrimidine photo-lyase {ECO:0000256|ARBA:ARBA00014046};
DE EC=4.1.99.3 {ECO:0000256|ARBA:ARBA00013149};
DE AltName: Full=DNA photolyase {ECO:0000256|ARBA:ARBA00031671};
GN ORFNames=RR46_12097 {ECO:0000313|EMBL:KPI95093.1};
OS Papilio xuthus (Asian swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=66420 {ECO:0000313|EMBL:KPI95093.1, ECO:0000313|Proteomes:UP000053268};
RN [1] {ECO:0000313|EMBL:KPI95093.1, ECO:0000313|Proteomes:UP000053268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPI95093.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPI95093.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in
CC DNA).; EC=4.1.99.3; Evidence={ECO:0000256|ARBA:ARBA00033999};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the DNA photolyase class-2 family.
CC {ECO:0000256|ARBA:ARBA00006409}.
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DR EMBL; KQ459597; KPI95093.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A194PQ52; -.
DR STRING; 66420.A0A194PQ52; -.
DR Proteomes; UP000053268; Unassembled WGS sequence.
DR GO; GO:0003904; F:deoxyribodipyrimidine photo-lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.80; -; 1.
DR Gene3D; 1.10.579.10; DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR036134; Crypto/Photolyase_FAD-like_sf.
DR InterPro; IPR036155; Crypto/Photolyase_N_sf.
DR InterPro; IPR008148; DNA_photolyase_2.
DR InterPro; IPR032673; DNA_photolyase_2_CS.
DR InterPro; IPR006050; DNA_photolyase_N.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00591; phr2; 1.
DR PANTHER; PTHR10211:SF0; DEOXYRIBODIPYRIMIDINE PHOTO-LYASE; 1.
DR PANTHER; PTHR10211; DEOXYRIBODIPYRIMIDINE PHOTOLYASE; 1.
DR Pfam; PF00875; DNA_photolyase; 1.
DR SUPFAM; SSF48173; Cryptochrome/photolyase FAD-binding domain; 1.
DR SUPFAM; SSF52425; Cryptochrome/photolyase, N-terminal domain; 1.
DR PROSITE; PS01084; DNA_PHOTOLYASES_2_2; 1.
DR PROSITE; PS51645; PHR_CRY_ALPHA_BETA; 1.
PE 3: Inferred from homology;
KW Chromophore {ECO:0000256|ARBA:ARBA00022991};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:KPI95093.1};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000053268};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 68..200
FT /note="Photolyase/cryptochrome alpha/beta"
FT /evidence="ECO:0000259|PROSITE:PS51645"
SQ SEQUENCE 509 AA; 58850 MW; 3FA57BCC457DEF41 CRC64;
MASAAKKIKL SAGTSNVENK RTQTSVAEFM NEIQKSREAT ADSITNFVFN KKRVRIISQE
QLVPDYCEGI VYWMSRDSRV QDNWAFLYAQ KLALKNEVPL HVCFCLIAKY LDASVRQFHF
LIKGLEKVAT ECKKLNISFH LLEGSGADAL PQWIIDHKIG AVVCDFNPPR TPMSWLEGAK
KKIKKDVPLI QVDAHNVVPC WVASEKLEYS ARTIRNKINS KLEEYLTEFP PVIKHPYTSK
FKPESIDWDK AIETREADKT VGPVEWASPG YDEAMKTLKS FLEKRLKIFA TKRNDPTQDA
LSNLSPWYHF GQISVQRVAL CVQKYKSQYT ESVNAYLEEA IVRRELADNF CFYNEHYDTI
KGASNWAQKT LDDHRKDKRT HIYTLEQLSK AETHDELWNS AQLQLVKEGK MHGFLRMYWC
KKILEWTPSP EDALKYAIYL NDHYSIDGRD PNGFVGCMWS ICGVHDQGWA ERAVFGKIRY
MNYNGCKRKF DIAAFVARYG GKQHKYKNN
//
